| pubmed-article:12460186 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C0337611 | lld:lifeskim |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C1817959 | lld:lifeskim |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:12460186 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:12460186 | pubmed:dateCreated | 2002-12-3 | lld:pubmed |
| pubmed-article:12460186 | pubmed:abstractText | Understanding the difference between the development of a productive T-cell response and tolerance is central to discerning how the immune system functions. Intravenous injection of soluble protein is thought to mimic the presentation of self-serum and orally introduced antigens. It is generally toleragenic. The current view is that this outcome reflects the failure of 'immunogenic' dendritic cells to relocate to the T-cell zone of the secondary lymphoid tissues. Here, using a peptide/I-Ek tetramer and antibodies to stain splenic sections, we showed that antigen-specific T cells were activated in the spleen within hours of injection or feeding of protein. The activated T cells were found to be located at the T-B junction, the bridging zone and the B-cell area, interacting directly with B cells. In addition, B cells gain the ability to present antigen. Our results suggest a way for T cells to be stimulated by blood-borne antigen presented by naïve B cells, a potential mechanism of tolerance induction. | lld:pubmed |
| pubmed-article:12460186 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12460186 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12460186 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12460186 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12460186 | pubmed:author | pubmed-author:DavisMark MMM | lld:pubmed |
| pubmed-article:12460186 | pubmed:author | pubmed-author:GreenbergHarr... | lld:pubmed |
| pubmed-article:12460186 | pubmed:author | pubmed-author:GütgemannInes... | lld:pubmed |
| pubmed-article:12460186 | pubmed:author | pubmed-author:DarlingJama... | lld:pubmed |
| pubmed-article:12460186 | pubmed:author | pubmed-author:ChienYueh-Hsi... | lld:pubmed |
| pubmed-article:12460186 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12460186 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12460186 | pubmed:pagination | 420-5 | lld:pubmed |
| pubmed-article:12460186 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12460186 | pubmed:articleTitle | A blood-borne antigen induces rapid T-B cell contact: a potential mechanism for tolerance induction. | lld:pubmed |
| pubmed-article:12460186 | pubmed:affiliation | Department of Microbiology and Immunology, Stanford University, Stanford, California, USA. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12460186 | lld:pubmed |
