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pubmed-article:1245795pubmed:abstractTextPlasma from an asymptomatic person with defects in blood coagulation, release of kinin, and evolution of fibrinolytic activity upon contact with a foreign surface was deficient in kininogen. The coagulation defect was identified as "Fitzgerald trait." A preparation of high molecular weight kininogen repaired the defects in clotting, kinin release and fibrinolysis, but a preparation of low molecular weight kininogen did not. Therefore, Fitzgerald factor appears to be a high molecular weight kininogen. The site of action of the kininogen appears to be after that of activated Hageman factor and kallikrein in the generation of clot-promoting activity through activation of plasma thromboplastin antecedent (PTA).lld:pubmed
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pubmed-article:1245795pubmed:articleTitleKininogen deficiency in Fitzgerald trait: role of high molecular weight kininogen in clotting and fibrinolysis.lld:pubmed
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