| pubmed-article:12456663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12456663 | lifeskim:mentions | umls-concept:C0949858 | lld:lifeskim |
| pubmed-article:12456663 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:12456663 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12456663 | lifeskim:mentions | umls-concept:C0439599 | lld:lifeskim |
| pubmed-article:12456663 | lifeskim:mentions | umls-concept:C1444662 | lld:lifeskim |
| pubmed-article:12456663 | pubmed:dateCreated | 2002-11-28 | lld:pubmed |
| pubmed-article:12456663 | pubmed:abstractText | Arteri-, corona-, toro- and roniviruses are evolutionarily related positive-strand RNA viruses, united in the order Nidovirales. The best studied nidoviruses, the corona- and arteriviruses, employ a unique transcription mechanism, which involves discontinuous RNA synthesis, a process resembling similarity-assisted copy-choice RNA recombination. During infection, multiple subgenomic (sg) mRNAs are transcribed from a mirror set of sg negative-strand RNA templates. The sg mRNAs all possess a short 5' common leader sequence, derived from the 5' end of the genomic RNA. The joining of the non-contiguous 'leader' and 'body' sequences presumably occurs during minus-strand synthesis. To study whether toroviruses use a similar transcription mechanism, we characterized the 5' termini of the genome and the four sg mRNAs of Berne virus (BEV). We show that BEV mRNAs 3-5 lack a leader sequence. Surprisingly, however, RNA 2 does contain a leader, identical to the 5'-terminal 18 residues of the genome. Apparently, BEV combines discontinuous and non-discontinuous RNA synthesis to produce its sg mRNAs. Our findings have important implications for the understanding of the mechanism and evolution of nidovirus transcription. | lld:pubmed |
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| pubmed-article:12456663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12456663 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12456663 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12456663 | pubmed:author | pubmed-author:de GrootR JRJ | lld:pubmed |
| pubmed-article:12456663 | pubmed:author | pubmed-author:RottierP J... | lld:pubmed |
| pubmed-article:12456663 | pubmed:author | pubmed-author:van VlietA... | lld:pubmed |
| pubmed-article:12456663 | pubmed:author | pubmed-author:SmitsS LSL | lld:pubmed |
| pubmed-article:12456663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12456663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12456663 | pubmed:pagination | 6571-80 | lld:pubmed |
| pubmed-article:12456663 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12456663 | pubmed:articleTitle | Discontinuous and non-discontinuous subgenomic RNA transcription in a nidovirus. | lld:pubmed |
| pubmed-article:12456663 | pubmed:affiliation | Institute of Virology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands. | lld:pubmed |
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