| pubmed-article:12456007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12456007 | lifeskim:mentions | umls-concept:C1024264 | lld:lifeskim |
| pubmed-article:12456007 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12456007 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:12456007 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12456007 | pubmed:dateCreated | 2002-11-28 | lld:pubmed |
| pubmed-article:12456007 | pubmed:abstractText | The soil fungus Trichoderma atroviride, a mycoparasite, responds to a number of external stimuli. In the presence of a fungal host, T. atroviride produces hydrolytic enzymes and coils around the host hyphae. In response to light or nutrient depletion, asexual sporulation is induced. In a biomimetic assay, different lectins induce coiling around nylon fibers; coiling in the absence of lectins can be induced by applying cyclic AMP (cAMP) or the heterotrimeric G-protein activator mastoparan. We isolated a T. atroviride G-protein alpha-subunit (Galpha) gene (tgal) belonging to the fungal subfamily with the highest similarity to the Galpha1 class. Generated transgenic lines that overexpress Galpha show very delayed sporulation and coil at a higher frequency. Furthermore, transgenic lines that express an activated mutant protein with no GTPase activity do not sporulate and coil at a higher frequency. Lines that express an antisense version of the gene are hypersporulating and coil at a much lower frequency in the biomimetic assay. The loss of Tgal in these mutants correlates with the loss of GTPase activity stimulated by the peptide toxin Mas-7. The application of Mas-7 to growing mycelial colonies raises intracellular cAMP levels, suggesting that Tgal can activate adenylyl cyclase. In contrast, cAMP levels and cAMP-dependent protein kinase activity drop when diffusible host signals are encountered and the mycoparasitism-related genes ech42 and prb1 are highly expressed. Mycoparasitic signaling is unlikely to be a linear pathway from host signals to increased cAMP levels. Our results demonstrate that the product of the tga1 gene is involved in both coiling and conidiation. | lld:pubmed |
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| pubmed-article:12456007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12456007 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12456007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12456007 | pubmed:author | pubmed-author:ChetIlanI | lld:pubmed |
| pubmed-article:12456007 | pubmed:author | pubmed-author:Rocha-Ramirez... | lld:pubmed |
| pubmed-article:12456007 | pubmed:author | pubmed-author:OmeroCarmiC | lld:pubmed |
| pubmed-article:12456007 | pubmed:author | pubmed-author:HorwitzBenjam... | lld:pubmed |
| pubmed-article:12456007 | pubmed:author | pubmed-author:Herrera-Estre... | lld:pubmed |
| pubmed-article:12456007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12456007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12456007 | pubmed:pagination | 594-605 | lld:pubmed |
| pubmed-article:12456007 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12456007 | pubmed:articleTitle | Trichoderma atroviride G-protein alpha-subunit gene tga1 is involved in mycoparasitic coiling and conidiation. | lld:pubmed |
| pubmed-article:12456007 | pubmed:affiliation | Department of Plant Genetic Engineering, Centro de Investigación y Estudios Avanzados, Unidad Irapuato, 36500 Irapuato, Guanajuato, México. | lld:pubmed |
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