| pubmed-article:12455041 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12455041 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:12455041 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:12455041 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:12455041 | lifeskim:mentions | umls-concept:C0205208 | lld:lifeskim |
| pubmed-article:12455041 | lifeskim:mentions | umls-concept:C0027766 | lld:lifeskim |
| pubmed-article:12455041 | lifeskim:mentions | umls-concept:C0037745 | lld:lifeskim |
| pubmed-article:12455041 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12455041 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12455041 | pubmed:dateCreated | 2002-11-27 | lld:pubmed |
| pubmed-article:12455041 | pubmed:abstractText | The aetiology of most childhood solid tumours (other than central nervous system [CNS] tumours) is unclear. To investigate whether certain environmental exposures may be involved, we have analysed for space-time clustering using population-based data from North West England for the period 1954-98. Knox tests for space-time interactions between cases were applied with fixed thresholds of close in space, <5 km, and close in time, <1 year apart. Addresses at birth and at diagnosis were used. Tests were repeated replacing geographical distance with distance to the Nth nearest neighbour. N was chosen such that the mean distance was 5 km. Data were also examined by a second order procedure based on K-functions. There was significant evidence of space-time clustering for Wilms' tumours (p = 0.03 and 0.04, using the geographical distance and nearest neighbour versions of the Knox test; and p = 0.07 and 0.03, using the geographical distance and nearest neighbour versions of the K-function method), and soft tissue sarcomas (p = 0.01, using both the geographical distance and nearest neighbour versions of the Knox test; and p = 0.001 and 0.002, using the geographical distance and nearest neighbour versions of the K-function method) based on time and location at birth, but not time and location at diagnosis. There was little or no evidence of space-time clustering amongst other diagnostic groups. These are the first results to demonstrate space-time clustering for childhood Wilms' tumours and soft tissue sarcomas. The results are consistent with environmental exposure hypotheses, relating to locations pre-natally or peri-natally. | lld:pubmed |
| pubmed-article:12455041 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12455041 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12455041 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12455041 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12455041 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12455041 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:12455041 | pubmed:author | pubmed-author:AlexanderFred... | lld:pubmed |
| pubmed-article:12455041 | pubmed:author | pubmed-author:EdenOsborn... | lld:pubmed |
| pubmed-article:12455041 | pubmed:author | pubmed-author:BirchJillian... | lld:pubmed |
| pubmed-article:12455041 | pubmed:author | pubmed-author:McNallyRichar... | lld:pubmed |
| pubmed-article:12455041 | pubmed:author | pubmed-author:KelseyAnna... | lld:pubmed |
| pubmed-article:12455041 | pubmed:author | pubmed-author:CairnsDonal... | lld:pubmed |
| pubmed-article:12455041 | pubmed:copyrightInfo | Copyright 2003 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:12455041 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12455041 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:12455041 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:12455041 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12455041 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12455041 | pubmed:pagination | 253-8 | lld:pubmed |
| pubmed-article:12455041 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
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| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:meshHeading | pubmed-meshheading:12455041... | lld:pubmed |
| pubmed-article:12455041 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12455041 | pubmed:articleTitle | Space-time clustering patterns in childhood solid tumours other than central nervous system tumours. | lld:pubmed |
| pubmed-article:12455041 | pubmed:affiliation | Cancer Research UK Paediatric and Familial Cancer Research Group, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, United Kingdom. richard.mcnally@man.ac.uk | lld:pubmed |
| pubmed-article:12455041 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12455041 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
