Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12454262rdf:typepubmed:Citationlld:pubmed
pubmed-article:12454262lifeskim:mentionsumls-concept:C0063164lld:lifeskim
pubmed-article:12454262lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:12454262lifeskim:mentionsumls-concept:C0017428lld:lifeskim
pubmed-article:12454262pubmed:dateCreated2002-11-27lld:pubmed
pubmed-article:12454262pubmed:abstractTextHMG-CoA reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonate, the rate-limiting step of eukaryotic isoprenoid biosynthesis, and is the main target of cholesterol-lowering drugs. The classical form of the enzyme is a transmembrane-protein anchored to the endoplasmic reticulum. However, during the last years several lines of evidence pointed to the existence of a second isoform of HMGCR localized in peroxisomes, where mevalonate is converted further to farnesyl diphosphate. This finding is relevant for our understanding of the complex regulation and compartmentalization of the cholesterogenic pathway. Here we review experimental evidence suggesting that the peroxisomal activity might be due to a second HMGCR gene in mammals. We then present a comprehensive analysis of completely sequenced eukaryotic genomes, as well as the human and mouse genome drafts. Our results provide evidence for a large number of independent duplications of HMGCR in all eukaryotic kingdoms, but not for a second gene in mammals. We conclude that the peroxisomal HMGCR activity in mammals is due to alternative targeting of the ER enzyme to peroxisomes by an as yet uncharacterized mechanism.lld:pubmed
pubmed-article:12454262pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12454262pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12454262pubmed:languageenglld:pubmed
pubmed-article:12454262pubmed:citationSubsetIMlld:pubmed
pubmed-article:12454262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12454262pubmed:statusMEDLINElld:pubmed
pubmed-article:12454262pubmed:authorpubmed-author:KrisansSkaidr...lld:pubmed
pubmed-article:12454262pubmed:authorpubmed-author:BreitlingRain...lld:pubmed
pubmed-article:12454262pubmed:ownerNLMlld:pubmed
pubmed-article:12454262pubmed:authorsCompleteYlld:pubmed
pubmed-article:12454262pubmed:pagination2031-6lld:pubmed
pubmed-article:12454262pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:12454262pubmed:articleTitleA second gene for peroxisomal HMG-CoA reductase? A genomic reassessment.lld:pubmed
pubmed-article:12454262pubmed:affiliationDepartment of Biology, San Diego State University, San Diego, CA, USA.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12454262lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12454262lld:pubmed