Linked Life Data

12446916

Source:http://linkedlifedata.com/resource/pubmed/id/12446916

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12446916rdf:typepubmed:Citationlld:pubmed
pubmed-article:12446916lifeskim:mentionsumls-concept:C0003761lld:lifeskim
pubmed-article:12446916lifeskim:mentionsumls-concept:C0007115lld:lifeskim
pubmed-article:12446916lifeskim:mentionsumls-concept:C0080103lld:lifeskim
pubmed-article:12446916lifeskim:mentionsumls-concept:C0040147lld:lifeskim
pubmed-article:12446916lifeskim:mentionsumls-concept:C0021968lld:lifeskim
pubmed-article:12446916lifeskim:mentionsumls-concept:C0199176lld:lifeskim
pubmed-article:12446916lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:12446916pubmed:dateCreated2002-11-26lld:pubmed
pubmed-article:12446916pubmed:abstractTextThe natural history of thyroid cancer and thyroiditis in relation to iodine prophylaxis in the region of Salta, Argentina, where goiter is common was investigated over a time span of 40 yr. For analysis of thyroid cancer, the specimens were divided into two periods. The first 15 yr (59 cases), including 5 yr before prophylaxis, was compared with the second 25 yr (182 cases), a period well after salt iodination. Papillary carcinomas formed the largest group of tumors in both periods, with a significant increase in their proportion in the second period (44 vs 60%, chi(2): p < 0.05), while the percentage of follicular and undifferentiated carcinomas decreased and medullary carcinoma remained about the same. The ratio of papillary to follicular carcinoma rose from 1.7:1 in the first period to 3.1:1 in the second. Four thyroid lymphomas of non-Hodgkin's B-cell type occurred in the second period in females over age 50. A severe lymphoid thyroiditis was present in the two cases with assessable background thyroid tissue. The frequency of moderate to severe lymphoid infiltrate in females rose from 2 of 12 (16.6%) in the preprophylaxis period to 34 of 114 (28.0%) in the last 25 yr after prophylaxis. After salt prophylaxis, thyroiditis was more frequent in patients with papillary carcinoma (36.2%) than in those with nonpapillary tumors (14.7%) (chi(2), p < 0.02). These observations indicate that a high dietary intake of iodine may be associated with a high frequency of papillary carcinoma and thyroiditis, and that thyroiditis is more commonly associated with papillary carcinoma than with other thyroid tumors. The occurrence of non-Hodgkin's lymphomas only in the postprophylaxis period may be linked to an increase in thyroiditis.lld:pubmed
pubmed-article:12446916pubmed:languageenglld:pubmed
pubmed-article:12446916pubmed:citationSubsetIMlld:pubmed
pubmed-article:12446916pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12446916pubmed:statusMEDLINElld:pubmed
pubmed-article:12446916pubmed:authorpubmed-author:HarachH...lld:pubmed
pubmed-article:12446916pubmed:authorpubmed-author:EscalanteDard...lld:pubmed
pubmed-article:12446916pubmed:authorpubmed-author:DayErnesto...lld:pubmed
pubmed-article:12446916pubmed:ownerNLMlld:pubmed
pubmed-article:12446916pubmed:authorsCompleteYlld:pubmed
pubmed-article:12446916pubmed:pagination175-81lld:pubmed
pubmed-article:12446916pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:12446916pubmed:articleTitleThyroid cancer and thyroiditis in Salta, Argentina: a 40-yr study in relation to iodine prophylaxis.lld:pubmed
pubmed-article:12446916pubmed:affiliationServices of Pathology, Dr A Oñativia Endocrinology and Metabolism Hospital, Salta, Argentina. rubenharach@ciudad.com.arlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12446916lld:pubmed