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| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C1260875 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C1154588 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:12446563 | lifeskim:mentions | umls-concept:C0257253 | lld:lifeskim |
| pubmed-article:12446563 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12446563 | pubmed:dateCreated | 2002-12-11 | lld:pubmed |
| pubmed-article:12446563 | pubmed:abstractText | A family of genetically and structurally homologous complexes, the proteasome lid, Cop9 signalosome (CSN) and eukaryotic translation initiation factor 3, mediate different regulatory pathways. The CSN functions in numerous eukaryotes as a regulator of development and signaling, yet until now no evidence for a complex has been found in Saccharomyces cerevisiae. We identified a group of proteins, including a homolog of Csn5/Jab1 and four uncharacterized PCI components, that interact in a manner suggesting they form a complex analogous to the CSN in S. cerevisiae. These newly identified subunits play a role in adaptation to pheromone signaling. Deletants for individual subunits enhance pheromone response and increase mating efficiency. Overexpression of individual subunits or a human homolog mitigates sst2-induced pheromone sensitivity. Csi1, a novel CSN interactor, exhibits opposite phenotypes. Deletants also accumulate Cdc53/cullin in a Rub1-modified form; however, this role of the CSN appears to be distinct from that in the mating pathway. | lld:pubmed |
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| pubmed-article:12446563 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12446563 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12446563 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12446563 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12446563 | pubmed:issn | 1469-221X | lld:pubmed |
| pubmed-article:12446563 | pubmed:author | pubmed-author:HofmannKayK | lld:pubmed |
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| pubmed-article:12446563 | pubmed:author | pubmed-author:Maytal-Kivity... | lld:pubmed |
| pubmed-article:12446563 | pubmed:author | pubmed-author:PiranRonR | lld:pubmed |
| pubmed-article:12446563 | pubmed:author | pubmed-author:PickElahE | lld:pubmed |
| pubmed-article:12446563 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12446563 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:12446563 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12446563 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12446563 | pubmed:pagination | 1215-21 | lld:pubmed |
| pubmed-article:12446563 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12446563 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12446563 | pubmed:articleTitle | COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. | lld:pubmed |
| pubmed-article:12446563 | pubmed:affiliation | Department of Biology and Institute for Catalysis Science and Technology, Technion-Israel Institute of Technology, 32000 Haifa, Israel. | lld:pubmed |
| pubmed-article:12446563 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12446563 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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