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pubmed-article:12441685pubmed:abstractTextPim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice, Pim-1 kinase is involved in the control of cell growth, differentiation and apoptosis. Expression of Pim-1 kinase can be stimulated by a variety of growth factors and regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Several signal transduction pathways may be associated with the regulation of Pim-1's expression; accumulating data support that the expression of Pim-1 protein is mediated through activation of JAK/STATs. Recent studies of Pim family kinases indicate that Pim-1 kinase plays important roles outside of the hematopoietic system as well.lld:pubmed
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pubmed-article:12441685pubmed:articleTitlePim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.lld:pubmed
pubmed-article:12441685pubmed:affiliationSchool of Molecular Biosciences Washington State University Pullman, Washington 99164-4234, USA.lld:pubmed
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