pubmed-article:12441685 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12441685 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:12441685 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
pubmed-article:12441685 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
pubmed-article:12441685 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
pubmed-article:12441685 | lifeskim:mentions | umls-concept:C1414387 | lld:lifeskim |
pubmed-article:12441685 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
pubmed-article:12441685 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
pubmed-article:12441685 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:12441685 | pubmed:dateCreated | 2002-11-20 | lld:pubmed |
pubmed-article:12441685 | pubmed:abstractText | Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice, Pim-1 kinase is involved in the control of cell growth, differentiation and apoptosis. Expression of Pim-1 kinase can be stimulated by a variety of growth factors and regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Several signal transduction pathways may be associated with the regulation of Pim-1's expression; accumulating data support that the expression of Pim-1 protein is mediated through activation of JAK/STATs. Recent studies of Pim family kinases indicate that Pim-1 kinase plays important roles outside of the hematopoietic system as well. | lld:pubmed |
pubmed-article:12441685 | pubmed:language | eng | lld:pubmed |
pubmed-article:12441685 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12441685 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12441685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:12441685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12441685 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12441685 | pubmed:month | Dec | lld:pubmed |
pubmed-article:12441685 | pubmed:issn | 1229-845X | lld:pubmed |
pubmed-article:12441685 | pubmed:author | pubmed-author:MeyerMM | lld:pubmed |
pubmed-article:12441685 | pubmed:author | pubmed-author:PetersenKK | lld:pubmed |
pubmed-article:12441685 | pubmed:author | pubmed-author:MagnusonN SNS | lld:pubmed |
pubmed-article:12441685 | pubmed:author | pubmed-author:WangZZ | lld:pubmed |
pubmed-article:12441685 | pubmed:author | pubmed-author:BhattacharyaN... | lld:pubmed |
pubmed-article:12441685 | pubmed:author | pubmed-author:WeaverMM | lld:pubmed |
pubmed-article:12441685 | pubmed:author | pubmed-author:GapterLL | lld:pubmed |
pubmed-article:12441685 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12441685 | pubmed:volume | 2 | lld:pubmed |
pubmed-article:12441685 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12441685 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12441685 | pubmed:pagination | 167-79 | lld:pubmed |
pubmed-article:12441685 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:12441685 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:12441685 | pubmed:articleTitle | Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis. | lld:pubmed |
pubmed-article:12441685 | pubmed:affiliation | School of Molecular Biosciences Washington State University Pullman, Washington 99164-4234, USA. | lld:pubmed |
pubmed-article:12441685 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12441685 | pubmed:publicationType | Review | lld:pubmed |
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