Linked Life Data

12438599

Source:http://linkedlifedata.com/resource/pubmed/id/12438599

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12438599rdf:typepubmed:Citationlld:pubmed
pubmed-article:12438599lifeskim:mentionsumls-concept:C0220847lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0021311lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0029246lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0019733lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0003316lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0042210lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0449450lld:lifeskim
pubmed-article:12438599lifeskim:mentionsumls-concept:C0205296lld:lifeskim
pubmed-article:12438599pubmed:dateCreated2002-11-19lld:pubmed
pubmed-article:12438599pubmed:abstractTextA polyepitopic CD8(+)-T-cell response is thought to be critical for control of hepatitis C virus (HCV) infection. Using transgenic mice, we analyzed the immunogenicity and dominance of most known HLA-A2.1 epitopes presented during infection by using vaccines that carry the potential to enter clinical trials: peptides, DNA, and recombinant adenoviruses. The vaccines capacity to induce specific cytotoxic T lymphocytes and interferon gamma-producing cells revealed that immunogenic epitopes are clustered in specific antigens. For two key antigens, flanking regions were shown to greatly enhance the scope of epitope recognition, whereas a DNA-adenovirus prime-boost vaccination strategy augmented epitope immunogenicity, even that of subdominant ones. The present study reveals a clustered organization of HCV immunogenic HLA.A2.1 epitopes and strategies to modulate their dominance.lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:languageenglld:pubmed
pubmed-article:12438599pubmed:citationSubsetIMlld:pubmed
pubmed-article:12438599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12438599pubmed:statusMEDLINElld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:KienyMarie...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:Op De...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:LoneYu ChunYClld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:HimoudiNourre...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:AbrahamJean-D...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:FournillierAn...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:JoubertAuréli...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:FreidaDelphin...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:LemonnierFran...lld:pubmed
pubmed-article:12438599pubmed:authorpubmed-author:InchauspéGene...lld:pubmed
pubmed-article:12438599pubmed:ownerNLMlld:pubmed
pubmed-article:12438599pubmed:authorsCompleteYlld:pubmed
pubmed-article:12438599pubmed:pagination12735-46lld:pubmed
pubmed-article:12438599pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:12438599pubmed:articleTitleComparative vaccine studies in HLA-A2.1-transgenic mice reveal a clustered organization of epitopes presented in hepatitis C virus natural infection.lld:pubmed
pubmed-article:12438599pubmed:affiliationUnité Mixte CNRS-BioMérieux, UMR 2142, Ecole Normale Supérieure, 46 Allée d'Italie, 69364 Lyon Cédex 07, France.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12438599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12438599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12438599lld:pubmed