Linked Life Data

12436049

Source:http://linkedlifedata.com/resource/pubmed/id/12436049

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pubmed-article:12436049pubmed:abstractTextLinkage studies alone do not produce sufficient resolution to narrow the location of a quantitative trait locus (QTL) to a small-enough chromosomal region for gene identification. One solution to this problem is to use interval-specific congenic recombinant (ISCR) lines to narrow the chromosomal interval known to contain the QTL. In previous work, we mapped four QTLs for differential ethanol sensitivity in the inbred long-sleep (ILS) and inbred short-sleep (ISS) strains and generated reciprocal congenic strains in which each full QTL interval from ILS was bred onto the ISS background and vice versa.lld:pubmed
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pubmed-article:12436049pubmed:authorpubmed-author:JohnsonThomas...lld:pubmed
pubmed-article:12436049pubmed:authorpubmed-author:BennettBethBlld:pubmed
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pubmed-article:12436049pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:12436049pubmed:articleTitleGenetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines.lld:pubmed
pubmed-article:12436049pubmed:affiliationInstitute for Behavioral Genetics, University of Colorado, Boulder 80309-0447, USA. bennettb@colorado.edulld:pubmed
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