| pubmed-article:12432931 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12432931 | lifeskim:mentions | umls-concept:C0243769 | lld:lifeskim |
| pubmed-article:12432931 | pubmed:dateCreated | 2002-11-15 | lld:pubmed |
| pubmed-article:12432931 | pubmed:abstractText | Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family. These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2. Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro. Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development. | lld:pubmed |
| pubmed-article:12432931 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12432931 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12432931 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12432931 | pubmed:author | pubmed-author:MurakamiMakot... | lld:pubmed |
| pubmed-article:12432931 | pubmed:author | pubmed-author:KudoIchiroI | lld:pubmed |
| pubmed-article:12432931 | pubmed:author | pubmed-author:NakataniYoshi... | lld:pubmed |
| pubmed-article:12432931 | pubmed:author | pubmed-author:TaniokaToshih... | lld:pubmed |
| pubmed-article:12432931 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12432931 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12432931 | pubmed:pagination | 383-99 | lld:pubmed |
| pubmed-article:12432931 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12432931 | pubmed:articleTitle | Prostaglandin E synthase. | lld:pubmed |
| pubmed-article:12432931 | pubmed:affiliation | Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Japan. mako@pharm.showa-u.ac.jp | lld:pubmed |
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