| pubmed-article:12431995 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12431995 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:12431995 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:12431995 | lifeskim:mentions | umls-concept:C1424764 | lld:lifeskim |
| pubmed-article:12431995 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:12431995 | lifeskim:mentions | umls-concept:C1335532 | lld:lifeskim |
| pubmed-article:12431995 | lifeskim:mentions | umls-concept:C0254662 | lld:lifeskim |
| pubmed-article:12431995 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12431995 | pubmed:dateCreated | 2003-2-17 | lld:pubmed |
| pubmed-article:12431995 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:abstractText | The correct targeting of modifying enzymes to ion channels and neurotransmitter receptors represents an important biological mechanism to control neuronal excitability. The recent cloning of protein kinase C-zeta interacting proteins (ZIP1, ZIP2) identified new scaffolds linking the atypical protein kinase PKC-zeta to target proteins. GABA(C) receptors are composed of three rho subunits (rho 1-3) that are highly expressed in the retina, where they are clustered at synaptic terminals of bipolar cells. A yeast two-hybrid screen for the GABA(C) receptor rho 3 subunit identified ZIP3, a new C-terminal splice variant of the ZIP protein family. ZIP3 was ubiquitously expressed in non-neuronal and neuronal tissues, including the retina. The rho 3-binding region of ZIP3 contained a ZZ-zinc finger domain, which interacted with 10 amino acids conserved in rho 1-3 but not in GABA(A) receptors. Consistently, only rho 1-3 subunits bound to ZIP3. ZIP3 formed dimers with ZIP1-3 and interacted with PKC-zeta and the shaker-type potassium channel subunit Kv beta 2. Different domains of ZIP3 interacted with PKC-zeta and the rho 3 subunit, and simultaneous assembly of ZIP3, PKC-zeta and rho 3 was demonstrated in vitro. Subcellular co-expression of ZIP3 binding partners in the retina supported the proposed protein interactions. Our results indicate the formation of a ternary postsynaptic complex containing PKC-zeta, ZIP3, and GABA(C) receptors. | lld:pubmed |
| pubmed-article:12431995 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12431995 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12431995 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12431995 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12431995 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12431995 | pubmed:author | pubmed-author:UNAIYY | lld:pubmed |
| pubmed-article:12431995 | pubmed:author | pubmed-author:CrociCristina... | lld:pubmed |
| pubmed-article:12431995 | pubmed:author | pubmed-author:BrändstatterJ... | lld:pubmed |
| pubmed-article:12431995 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12431995 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:12431995 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12431995 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12431995 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12431995 | pubmed:pagination | 6128-35 | lld:pubmed |
| pubmed-article:12431995 | pubmed:dateRevised | 2009-4-7 | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:meshHeading | pubmed-meshheading:12431995... | lld:pubmed |
| pubmed-article:12431995 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12431995 | pubmed:articleTitle | ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. | lld:pubmed |
| pubmed-article:12431995 | pubmed:affiliation | Emil-Fischer-Zentrum, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstrasse 17, 91054 Erlangen, Germany. | lld:pubmed |
| pubmed-article:12431995 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12431995 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2569 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:2570 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:8514 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:8878 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:200959 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:25522 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:29694 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:29695 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:29738 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:113894 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:170840 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| entrez-gene:192258 | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12431995 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12431995 | lld:pubmed |
