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12431846

Source:http://linkedlifedata.com/resource/pubmed/id/12431846

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pubmed-article:12431846pubmed:dateCreated2002-11-14lld:pubmed
pubmed-article:12431846pubmed:abstractTextConsistent with human literature, previous studies identified attention-enhancing effects of nicotine in rats, using a 5-choice task. The present study addressed the influence of repeated exposure to nicotine on these effects. Over six weeks, the effects of nicotine (0.0, 0.05 and 0.2 mg/kg) given ten min before sessions were tested each week. In addition, rats were injected daily two hours after sessions. In the first week, when these post-session injections were of saline for all rats, pre-session nicotine had profound rate-disruptive effects at the larger dose. In weeks 2-6, when half the rats received post-session injections of saline and the other half of nicotine (0.4 mg/kg), the disruptive effects of pre-session nicotine had disappeared and it enhanced attentional performance on all response indices. These effects did not differ significantly between post-session treatment groups or weeks, although they appeared less pronounced in the last two weeks. When tested under modified task parameters in weeks 9 and 10, nicotine (0.1 mg/kg) robustly enhanced performance in both groups despite continuing daily post-session administration of nicotine or saline. These studies provide evidence that, following tolerance to initial disruptive effects, the nicotine-induced attentional enhancement is stable across lengthy periods of chronic exposure. This is important for potential therapeutic applications of the drug and indicates that these effects can be a continuous motive for smoking behavior.lld:pubmed
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pubmed-article:12431846pubmed:authorpubmed-author:StolermanI...lld:pubmed
pubmed-article:12431846pubmed:authorpubmed-author:HahnBBlld:pubmed
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pubmed-article:12431846pubmed:pagination712-22lld:pubmed
pubmed-article:12431846pubmed:dateRevised2011-5-18lld:pubmed
pubmed-article:12431846pubmed:articleTitleNicotine-induced attentional enhancement in rats: effects of chronic exposure to nicotine.lld:pubmed
pubmed-article:12431846pubmed:affiliationSection of Behavioural Pharmacology, Institute of Psychiatry, King's College London, De Crespigny Park, SE5 8AF, London, UK. b.hahn@iop.kl.ac.uklld:pubmed
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