Linked Life Data

12426369

Source:http://linkedlifedata.com/resource/pubmed/id/12426369

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12426369rdf:typepubmed:Citationlld:pubmed
pubmed-article:12426369lifeskim:mentionsumls-concept:C0038454lld:lifeskim
pubmed-article:12426369lifeskim:mentionsumls-concept:C0085139lld:lifeskim
pubmed-article:12426369lifeskim:mentionsumls-concept:C0032863lld:lifeskim
pubmed-article:12426369lifeskim:mentionsumls-concept:C0205288lld:lifeskim
pubmed-article:12426369lifeskim:mentionsumls-concept:C1705994lld:lifeskim
pubmed-article:12426369lifeskim:mentionsumls-concept:C1513492lld:lifeskim
pubmed-article:12426369lifeskim:mentionsumls-concept:C0332120lld:lifeskim
pubmed-article:12426369pubmed:issue22lld:pubmed
pubmed-article:12426369pubmed:dateCreated2002-11-11lld:pubmed
pubmed-article:12426369pubmed:abstractTextWe used cryo-electron microscopy and image reconstruction to investigate the structure and microtubule-binding configurations of dimeric non-claret disjunctional (ncd) motor domains under various nucleotide conditions, and applied molecular docking using ncd's dimeric X-ray structure to generate a mechanistic model for force transduction. To visualize the alpha-helical coiled-coil neck better, we engineered an SH3 domain to the N-terminal end of our ncd construct (296-700). Ncd exhibits strikingly different nucleotide-dependent three-dimensional conformations and microtubule-binding patterns from those of conventional kinesin. In the absence of nucleotide, the neck adapts a configuration close to that found in the X-ray structure with stable interactions between the neck and motor core domain. Minus-end-directed movement is based mainly on two key events: (i) the stable neck-core interactions in ncd generate a binding geometry between motor and microtubule which places the motor ahead of its cargo in the minus-end direction; and (ii) after the uptake of ATP, the two heads rearrange their position relative to each other in a way that promotes a swing of the neck in the minus-end direction.lld:pubmed
pubmed-article:12426369pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:languageenglld:pubmed
pubmed-article:12426369pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:citationSubsetIMlld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12426369pubmed:statusMEDLINElld:pubmed
pubmed-article:12426369pubmed:monthNovlld:pubmed
pubmed-article:12426369pubmed:issn0261-4189lld:pubmed
pubmed-article:12426369pubmed:authorpubmed-author:MüllerJensJlld:pubmed
pubmed-article:12426369pubmed:authorpubmed-author:GoldieKenneth...lld:pubmed
pubmed-article:12426369pubmed:authorpubmed-author:HoengerAndrea...lld:pubmed
pubmed-article:12426369pubmed:authorpubmed-author:WendtThomas...lld:pubmed
pubmed-article:12426369pubmed:authorpubmed-author:VolkmannNiels...lld:pubmed
pubmed-article:12426369pubmed:authorpubmed-author:MandelkowEckh...lld:pubmed
pubmed-article:12426369pubmed:authorpubmed-author:SkiniotisGeor...lld:pubmed
pubmed-article:12426369pubmed:issnTypePrintlld:pubmed
pubmed-article:12426369pubmed:day15lld:pubmed
pubmed-article:12426369pubmed:volume21lld:pubmed
pubmed-article:12426369pubmed:ownerNLMlld:pubmed
pubmed-article:12426369pubmed:authorsCompleteYlld:pubmed
pubmed-article:12426369pubmed:pagination5969-78lld:pubmed
pubmed-article:12426369pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
pubmed-article:12426369pubmed:meshHeadingpubmed-meshheading:12426369...lld:pubmed
More...