| pubmed-article:12426130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12426130 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:12426130 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12426130 | lifeskim:mentions | umls-concept:C0015625 | lld:lifeskim |
| pubmed-article:12426130 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:12426130 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12426130 | lifeskim:mentions | umls-concept:C0168430 | lld:lifeskim |
| pubmed-article:12426130 | pubmed:dateCreated | 2002-11-11 | lld:pubmed |
| pubmed-article:12426130 | pubmed:abstractText | Fanconi anemia (FA) is an autosomal recessive disorder characterized by diverse developmental abnormalities, progressive bone marrow failure, and a markedly increased incidence of malignancy. FA cells are hypersensitive to DNA cross-linking agents, suggesting a general defect in the repair of DNA cross-links. Some forms of hexavalent chromium [Cr(VI)] are implicated as respiratory carcinogens and induce several types of DNA lesions, including ternary DNA-Cr-DNA interstrand cross-links (Cr-DDC). We hypothesized that human FA complementation group A (FA-A) cells would be hypersensitive to Cr(VI) and Cr(VI)-induced apoptosis. Using phosphatidylserine translocation and caspase-3 activation, human FA-A fibroblasts were found to be markedly hypersensitive to chromium-induced apoptosis compared with CRL-1634 cells, which are normal human foreskin fibroblasts (CRL). The clonogenicity of FA-A cells was also significantly decreased compared with CRL cells after Cr(VI) treatment. There was no significant difference in either Cr(VI) uptake or Cr-DNA adduct formation between FA-A and CRL cells. These results show that FA-A cells are hypersensitive to Cr(VI) and Cr-induced apoptosis and that this hypersensitivity is not due to increased Cr(VI) uptake or increased Cr-DNA adduct formation. The results also suggest that Cr-DDC may be proapoptotic lesions. These results are the first to show that FA cells are hypersensitive to an environmentally relevant DNA cross-linking agent. | lld:pubmed |
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| pubmed-article:12426130 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12426130 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12426130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12426130 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12426130 | pubmed:issn | 0091-6765 | lld:pubmed |
| pubmed-article:12426130 | pubmed:author | pubmed-author:HaLinanL | lld:pubmed |
| pubmed-article:12426130 | pubmed:author | pubmed-author:CeryakSusanS | lld:pubmed |
| pubmed-article:12426130 | pubmed:author | pubmed-author:PatiernoSteve... | lld:pubmed |
| pubmed-article:12426130 | pubmed:author | pubmed-author:PritchardDary... | lld:pubmed |
| pubmed-article:12426130 | pubmed:author | pubmed-author:VilcheckSusan... | lld:pubmed |
| pubmed-article:12426130 | pubmed:author | pubmed-author:O'BrienTravis... | lld:pubmed |
| pubmed-article:12426130 | pubmed:author | pubmed-author:FornsaglioJam... | lld:pubmed |
| pubmed-article:12426130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12426130 | pubmed:volume | 110 Suppl 5 | lld:pubmed |
| pubmed-article:12426130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12426130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12426130 | pubmed:pagination | 773-7 | lld:pubmed |
| pubmed-article:12426130 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
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| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:meshHeading | pubmed-meshheading:12426130... | lld:pubmed |
| pubmed-article:12426130 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12426130 | pubmed:articleTitle | Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity. | lld:pubmed |
