| pubmed-article:12419229 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12419229 | lifeskim:mentions | umls-concept:C0027270 | lld:lifeskim |
| pubmed-article:12419229 | lifeskim:mentions | umls-concept:C0030016 | lld:lifeskim |
| pubmed-article:12419229 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:12419229 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12419229 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12419229 | pubmed:dateCreated | 2002-11-6 | lld:pubmed |
| pubmed-article:12419229 | pubmed:abstractText | Transcriptional repression is based on the selective actions of recruited corepressor complexes, including those with enzymatic activities. One well-characterized developmentally important corepressor is the C-terminal binding protein (CtBP). Although intriguingly related in sequence to D2 hydroxyacid dehydrogenases, the mechanism by which CtBP functions remains unclear. We report here biochemical and crystallographic studies which reveal that CtBP is a functional dehydrogenase. In addition, both a cofactor-dependent conformational change, with NAD(+) and NADH being equivalently effective, and the active site residues are linked to the binding of the PXDLS consensus recognition motif on repressors, such as E1A and RIP140. Together, our data suggest that CtBP is an NAD(+)-regulated component of critical complexes for specific repression events in cells. | lld:pubmed |
| pubmed-article:12419229 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12419229 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12419229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419229 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12419229 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12419229 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:EdwardsThomas... | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:RoseDavid WDW | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:RosenfeldMich... | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:CarlsonJustin... | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:KumarVivekV | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:EscalanteCarl... | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:AggarwalAneel... | lld:pubmed |
| pubmed-article:12419229 | pubmed:author | pubmed-author:OhgiKenneth... | lld:pubmed |
| pubmed-article:12419229 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12419229 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:12419229 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12419229 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12419229 | pubmed:pagination | 857-69 | lld:pubmed |
| pubmed-article:12419229 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:meshHeading | pubmed-meshheading:12419229... | lld:pubmed |
| pubmed-article:12419229 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12419229 | pubmed:articleTitle | Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. | lld:pubmed |
| pubmed-article:12419229 | pubmed:affiliation | Department of Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA. | lld:pubmed |
| pubmed-article:12419229 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12419229 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:1487 | entrezgene:pubmed | pubmed-article:12419229 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12419229 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12419229 | lld:pubmed |
