| pubmed-article:12418028 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C0042313 | lld:lifeskim |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C0991566 | lld:lifeskim |
| pubmed-article:12418028 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12418028 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12418028 | pubmed:dateCreated | 2002-11-5 | lld:pubmed |
| pubmed-article:12418028 | pubmed:abstractText | The current delivery system of antibiotics for the treatment of osteomyelitis uses polymethylmethacrylate (PMMA) beads as a local drug-release agent. The nonbiodegradable nature of the PMMA, however, necessitates a second operation to remove the beads. This article explores the alternative of using biodegradable polymers as antibiotic beads for a long-term drug release in vivo. To manufacture an antibiotic bead, lactide-glycolide copolymers were mixed with vancomycin. The mixture was compressed and sintered at 55 degrees C to form beads 8 mm in diameter. An in vivo animal model was proposed to characterize the elution rate of antibiotic over a 55-day period. Biodegradable beads released high concentrations of antibiotic (well above the breakpoint sensitivity concentration) in vivo for the period of time needed to treat bone infection; that is, 4-6 weeks. A bacterial inhibition test was also carried out to determine the relative activity of the released antibiotics. The diameter of the sample inhibition zone ranged from 8 to 18 mm, which is equivalent to 9.1 to 100% of relative activity. In addition, the antibiotic concentration of systemic blood was found to be very low. Antibiotic-impregnated biodegradable beads may have a potential role in the prevention and management of surgical infections. | lld:pubmed |
| pubmed-article:12418028 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12418028 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12418028 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12418028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12418028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12418028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12418028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12418028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12418028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12418028 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12418028 | pubmed:issn | 0021-9304 | lld:pubmed |
| pubmed-article:12418028 | pubmed:author | pubmed-author:LinSong-ShuSS | lld:pubmed |
| pubmed-article:12418028 | pubmed:author | pubmed-author:LiuShih-JungS... | lld:pubmed |
| pubmed-article:12418028 | pubmed:author | pubmed-author:ChanErr-Cheng... | lld:pubmed |
| pubmed-article:12418028 | pubmed:author | pubmed-author:Wen-Neng... | lld:pubmed |
| pubmed-article:12418028 | pubmed:copyrightInfo | Copyright 2002 Wiley Periodicals, Inc. | lld:pubmed |
| pubmed-article:12418028 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12418028 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:12418028 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12418028 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12418028 | pubmed:pagination | 807-13 | lld:pubmed |
| pubmed-article:12418028 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:meshHeading | pubmed-meshheading:12418028... | lld:pubmed |
| pubmed-article:12418028 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12418028 | pubmed:articleTitle | In vivo release of vancomycin from biodegradable beads. | lld:pubmed |
| pubmed-article:12418028 | pubmed:affiliation | Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan. | lld:pubmed |
| pubmed-article:12418028 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12418028 | lld:pubmed |
