Linked Life Data

12417990

Source:http://linkedlifedata.com/resource/pubmed/id/12417990

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pubmed-article:12417990pubmed:abstractTextEvaluation of water diffusion in the brain has revealed both fast- and slow-diffusing water populations. It has been suggested that these populations represent extra- and intracellular water, respectively. We have identified and characterized both populations in the intracellular space of the Xenopus oocyte. We have also determined their T(1) and T(2) relaxation properties. The fast and slow intracellular populations have diffusion coefficients of 1.06 +/- 0.05 microm(2)/ms and 0.16 +/- 0.02 microm(2)/ms, respectively, with the fast fraction representing 89% +/- 1% of the total water signal. These values are quite similar to those for total water in brain and are observed in the absence of signal from the perfusate (extracellular) water population. Volumetric swelling (16% +/- 4%) of the oocyte in hypoosmotic media increased the diffusion coefficients of both intracellular populations (fast = 1.27 +/- 0.03 microm(2)/ms, slow = 0.22 +/- 0.02 microm(2)/ms), but did not change their relative signal fractions. This phenomenon runs counter to the effects observed in brain injury, following which the apparent diffusion coefficient (ADC) decreases 30-50%. The results presented herein suggest that this ADC decrease in brain occurs despite cell swelling, which by itself would be expected to induce an increase in intracellular diffusion coefficients.lld:pubmed
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pubmed-article:12417990pubmed:authorpubmed-author:NeilJeffrey...lld:pubmed
pubmed-article:12417990pubmed:authorpubmed-author:SehyJonathan...lld:pubmed
pubmed-article:12417990pubmed:copyrightInfoCopyright 2002 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:12417990pubmed:volume48lld:pubmed
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pubmed-article:12417990pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:12417990pubmed:articleTitleEvidence that both fast and slow water ADC components arise from intracellular space.lld:pubmed
pubmed-article:12417990pubmed:affiliationProgram in Molecular Cell Biology, Washington University, St Louis, Missouri 63110, USA.lld:pubmed
pubmed-article:12417990pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12417990pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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