| pubmed-article:12414983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C0021400 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12414983 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12414983 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:12414983 | pubmed:dateCreated | 2002-11-4 | lld:pubmed |
| pubmed-article:12414983 | pubmed:abstractText | The primary influenza A virus-specific CD8(+)-T-cell responses measured by tetramer staining of spleen, lymph node, and bronchoalveolar lavage (BAL) lymphocyte populations were similar in magnitude for conventional I-A(b+/+) and CD4(+)-T-cell-deficient I-A(b-/-) mice. Comparable levels of virus-specific cytotoxic-T-lymphocyte activity were detected in the inflammatory exudate recovered by BAL following challenge. However, both the size of the memory T-cell pool and the magnitude of the recall response in the lymphoid tissues (but not the BAL specimens) were significantly diminished in mice lacking the CD4(+) subset. Also, the rate of virus elimination from the infected respiratory tract slowed at low virus loads following challenge of naïve and previously immunized I-A(b-/-) mice. Thus, though the capacity to mediate the CD8(+)-T-cell effector function is broadly preserved in the absence of concurrent CD4(+)-T-cell help, both the maintenance and recall of memory are compromised and the clearance of residual virus is delayed. These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection. | lld:pubmed |
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| pubmed-article:12414983 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12414983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12414983 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12414983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12414983 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12414983 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12414983 | pubmed:author | pubmed-author:NowakMartin... | lld:pubmed |
| pubmed-article:12414983 | pubmed:author | pubmed-author:BelzGabrielle... | lld:pubmed |
| pubmed-article:12414983 | pubmed:author | pubmed-author:DiazGabrielaG | lld:pubmed |
| pubmed-article:12414983 | pubmed:author | pubmed-author:DohertyPeter... | lld:pubmed |
| pubmed-article:12414983 | pubmed:author | pubmed-author:WodarzDominik... | lld:pubmed |
| pubmed-article:12414983 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12414983 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:12414983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12414983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12414983 | pubmed:pagination | 12388-93 | lld:pubmed |
| pubmed-article:12414983 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12414983 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12414983 | pubmed:articleTitle | Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice. | lld:pubmed |
| pubmed-article:12414983 | pubmed:affiliation | Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. | lld:pubmed |
| pubmed-article:12414983 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12414983 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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