| pubmed-article:12414620 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12414620 | lifeskim:mentions | umls-concept:C0543482 | lld:lifeskim |
| pubmed-article:12414620 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:12414620 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:12414620 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:12414620 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:12414620 | pubmed:dateCreated | 2002-11-4 | lld:pubmed |
| pubmed-article:12414620 | pubmed:abstractText | Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRCs into three groups: MINT++ (>2), MINT+ (1-2), and MINT- (0 markers methylated). The MSS/MSI-L/MINT++ group was indistinguishable from the MSI-H/MINT++ group with respect to methylation of p16(INK4a), p14(ARF), and RIZ1, and multiple morphological features. The only significant difference between MSI-H and non-MSI-H MINT++ cancers was the higher frequency of K-ras mutation (P < 0.004) and lower frequency of hMLH1 methylation (P < 0.001) in the latter. These data demonstrate that the separation of CRC into two nonoverlapping groups (MSI-H versus MSS/MSI-L) is a misleading oversimplification. | lld:pubmed |
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| pubmed-article:12414620 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12414620 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12414620 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12414620 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12414620 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12414620 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:WalshMichael... | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:LeggettBarbar... | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:JassJeremy... | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:MeltzerStephe... | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:YoungJoanneJ | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:PurdieDavidD | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:WhitehallVick... | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:PandeyaNirmal... | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:WynterCoral... | lld:pubmed |
| pubmed-article:12414620 | pubmed:author | pubmed-author:SimmsLisa ALA | lld:pubmed |
| pubmed-article:12414620 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12414620 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12414620 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:12414620 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12414620 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12414620 | pubmed:pagination | 6011-4 | lld:pubmed |
| pubmed-article:12414620 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12414620 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12414620 | pubmed:articleTitle | Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. | lld:pubmed |
| pubmed-article:12414620 | pubmed:affiliation | Conjoint Gastroenterology Laboratory, Clinical Research Centre, Royal Brisbane Hospital Research Foundation, Queensland 4029, Australia. vickiWh@qimr.edu.au | lld:pubmed |
| pubmed-article:12414620 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12414620 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12414620 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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