| pubmed-article:12409990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12409990 | lifeskim:mentions | umls-concept:C0012522 | lld:lifeskim |
| pubmed-article:12409990 | lifeskim:mentions | umls-concept:C0012010 | lld:lifeskim |
| pubmed-article:12409990 | lifeskim:mentions | umls-concept:C0003467 | lld:lifeskim |
| pubmed-article:12409990 | lifeskim:mentions | umls-concept:C0006462 | lld:lifeskim |
| pubmed-article:12409990 | lifeskim:mentions | umls-concept:C0012381 | lld:lifeskim |
| pubmed-article:12409990 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12409990 | pubmed:dateCreated | 2002-10-31 | lld:pubmed |
| pubmed-article:12409990 | pubmed:abstractText | Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety. We investigated the ability of a number of putative anxiolytic agents to alleviate these anxiety states using the elevated plus-maze. Rats in the cocaine condition received either saline or cocaine (20 mg/kg) 40 min prior to testing; those in the withdrawal condition were tested 48 h following a chronic treatment regime (saline or cocaine 20 mg/kg per day for 14 days). Prior to testing, animals received a benzodiazepine (1.0 or 2.0 mg/kg diazepam), a serotonergic agonist (0.5 or 1.0 mg/kg buspirone), an antihistamine (50 mg/kg dimenhydrinate or 27 mg/kg diphenhydramine) or a saline injection. All drugs were administered intraperitoneally. Cocaine administration and cocaine withdrawal reduced the percentage time spent on and the number of entries into the open arms. Diazepam dose-dependently alleviated cocaine withdrawal-induced anxiety and non-significantly attenuated cocaine-induced anxiety. Buspirone, dimenhydrinate and diphenhydramine did not consistently alleviate the anxiety caused by either cocaine pre-treatment regime; in the saline conditions, however, each of these treatments was anxiogenic. In summary, benzodiazepines alleviated cocaine-induced anxiety, while future research on the ability of serotonergic and antihistaminergic drugs to alleviate these anxiety states is warranted. | lld:pubmed |
| pubmed-article:12409990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12409990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409990 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12409990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12409990 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12409990 | pubmed:issn | 0955-8810 | lld:pubmed |
| pubmed-article:12409990 | pubmed:author | pubmed-author:PateyE HEH | lld:pubmed |
| pubmed-article:12409990 | pubmed:author | pubmed-author:OlmsteadM CMC | lld:pubmed |
| pubmed-article:12409990 | pubmed:author | pubmed-author:JackmanS LSL | lld:pubmed |
| pubmed-article:12409990 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12409990 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12409990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12409990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12409990 | pubmed:pagination | 511-23 | lld:pubmed |
| pubmed-article:12409990 | pubmed:dateRevised | 2009-7-7 | lld:pubmed |
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| pubmed-article:12409990 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12409990 | pubmed:articleTitle | Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine. | lld:pubmed |
| pubmed-article:12409990 | pubmed:affiliation | Department of Psychology, Queen's University, Kingston, Ontario, Canada. | lld:pubmed |
| pubmed-article:12409990 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12409990 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12409990 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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