| pubmed-article:12407706 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C0023745 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C0449295 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:12407706 | lifeskim:mentions | umls-concept:C1707959 | lld:lifeskim |
| pubmed-article:12407706 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12407706 | pubmed:dateCreated | 2002-10-30 | lld:pubmed |
| pubmed-article:12407706 | pubmed:abstractText | IDDM10 on chromosome 10p11-q11 has been identified as a putative diabetes susceptibility locus through affected sib-pair (ASP) linkage analysis in UK nuclear families [Davies et al., 1994: Nature 371:130-136; Reed et al., 1997: Hum Mol Genet 6:1011-1016; Mein et al., 1998: Nat Genet 19:297-300]. We extended analysis of linkage to type 1 diabetes in this region by typing a total of 61 markers in a maximum of 418 UK sib-pairs (UK418; peak MLS = 3.84). We then stratified the dataset based on analyses performed previously by both our group [Mein et al., 1998: Nat Genet 19:297-300] and others [Paterson et al., 1999: Hum Hered 49:197-204; Paterson and Petronis, 1999a: Am J Med Genet 84:15-19; Paterson and Petronis, 2000a: J Med Genet 37:186-191; Paterson and Petronis, b: Eur J Hum Genet 8:145-148] and used a permutation procedure to assess the significance of the results. We conclude that the results obtained had a high probability of occurring by chance alone. These data highlight the limitations of stratifying small datasets (n < 500) by additional criteria and the recurrent problems of multiple testing in genetic analysis. | lld:pubmed |
| pubmed-article:12407706 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12407706 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12407706 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12407706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12407706 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12407706 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12407706 | pubmed:issn | 0148-7299 | lld:pubmed |
| pubmed-article:12407706 | pubmed:author | pubmed-author:ToddJohn AJA | lld:pubmed |
| pubmed-article:12407706 | pubmed:author | pubmed-author:KoelemanBobby... | lld:pubmed |
| pubmed-article:12407706 | pubmed:author | pubmed-author:JohnsonGillia... | lld:pubmed |
| pubmed-article:12407706 | pubmed:copyrightInfo | Copyright 2002 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:12407706 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12407706 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:12407706 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:12407706 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12407706 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12407706 | pubmed:pagination | 158-66 | lld:pubmed |
| pubmed-article:12407706 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12407706 | pubmed:meshHeading | pubmed-meshheading:12407706... | lld:pubmed |
| pubmed-article:12407706 | pubmed:meshHeading | pubmed-meshheading:12407706... | lld:pubmed |
| pubmed-article:12407706 | pubmed:meshHeading | pubmed-meshheading:12407706... | lld:pubmed |
| pubmed-article:12407706 | pubmed:meshHeading | pubmed-meshheading:12407706... | lld:pubmed |
| pubmed-article:12407706 | pubmed:meshHeading | pubmed-meshheading:12407706... | lld:pubmed |
| pubmed-article:12407706 | pubmed:meshHeading | pubmed-meshheading:12407706... | lld:pubmed |
| pubmed-article:12407706 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12407706 | pubmed:articleTitle | Limitations of stratifying sib-pair data in common disease linkage studies: an example using chromosome 10p14-10q11 in type 1 diabetes. | lld:pubmed |
| pubmed-article:12407706 | pubmed:affiliation | JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom. | lld:pubmed |
| pubmed-article:12407706 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12407706 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12407706 | lld:pubmed |
