Linked Life Data

12400007

Source:http://linkedlifedata.com/resource/pubmed/id/12400007

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pubmed-article:12400007pubmed:dateCreated2002-10-25lld:pubmed
pubmed-article:12400007pubmed:abstractTextJunctional adhesion molecule (JAM) is a Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which localizes at tight junctions (TJs). Claudin is a key cell-cell adhesion molecule that forms TJ strands at TJs. JAM is associated with claudin through their cytoplasmic tail-binding protein, ZO-1. JAM is furthermore associated with Par-3, a cell polarity protein which forms a ternary complex with Par-6 and atypical protein kinase C. Nectin is another Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which localizes at adherens junctions (AJs). Nectin is associated with E-cadherin through their respective cytoplasmic tail-binding proteins, afadin and catenins, and involved in the formation of AJs cooperatively with E-cadherin. We show here that nectin is furthermore involved in the localization of JAM at TJs. During the formation of the junctional complex consisting of AJs and TJs in Madin-Darby canine kidney (MDCK) cells, JAM was recruited to the nectin-based cell-cell adhesion sites. This recruitment of JAM was inhibited by nectin inhibitors, which inhibited the trans-interaction of nectin. Microbeads coated with the extracellular fragment of nectin, that interacted with cellular nectin, also recruited JAM to the bead-MDCK cell contact sites. Furthermore, when cadherin-deficient L fibroblasts stably expressing both exogenous JAM and nectin (nectin-JAM-L cells) were co-cultured with L fibroblasts expressing only nectin (nectin-L cells), JAM was concentrated at the cell-cell adhesion sites between nectin-JAM-L and nectin-L cells without the trans-interaction of JAM. Analyses of the localization and immunoprecipitation of JAM revealed that it was associated with nectin through afadin and ZO-1. These results suggest that nectin has a role in the localization of JAM at TJs in the process of the formation of the junctional complex in epithelial cells.lld:pubmed
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pubmed-article:12400007pubmed:authorpubmed-author:TakaiYoshimiYlld:pubmed
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pubmed-article:12400007pubmed:dateRevised2006-10-25lld:pubmed
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pubmed-article:12400007pubmed:year2002lld:pubmed
pubmed-article:12400007pubmed:articleTitleInvolvement of nectin in the localization of junctional adhesion molecule at tight junctions.lld:pubmed
pubmed-article:12400007pubmed:affiliationDepartment of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan.lld:pubmed
pubmed-article:12400007pubmed:publicationTypeJournal Articlelld:pubmed
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