| pubmed-article:12399478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12399478 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12399478 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:12399478 | lifeskim:mentions | umls-concept:C1304680 | lld:lifeskim |
| pubmed-article:12399478 | lifeskim:mentions | umls-concept:C1511681 | lld:lifeskim |
| pubmed-article:12399478 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:12399478 | lifeskim:mentions | umls-concept:C1261512 | lld:lifeskim |
| pubmed-article:12399478 | lifeskim:mentions | umls-concept:C0699795 | lld:lifeskim |
| pubmed-article:12399478 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:12399478 | pubmed:dateCreated | 2002-10-25 | lld:pubmed |
| pubmed-article:12399478 | pubmed:abstractText | In prokaryotic genomes, some DNA methyltransferases form a restriction-modification gene complex, but some others are present by themselves. Dcm gene product, one of these orphan methyltransferases found in Escherichia coli and related bacteria, methylates DNA to generate 5'-C(m)CWGG just as some of its eukaryotic homologues do. Vsr mismatch repair function of an adjacent gene prevents C-to-T mutagenesis enhanced by this methylation but promotes other types of mutation and likely has affected genome evolution. The reason for the existence of the dcm-vsr gene pair has been unclear. Earlier we found that several restriction-modification gene complexes behave selfishly in that their loss from a cell leads to cell killing through restriction attack on the genome. There is also increasing evidence for their potential mobility. EcoRII restriction-modification gene complex recognizes the same sequence as Dcm, and its methyltransferase is phylogenetically related to Dcm. In the present work, we found that stabilization of maintenance of a plasmid by linkage of EcoRII gene complex, likely through postsegregational cell killing, is diminished by dcm function. Disturbance of EcoRII restriction-modification gene complex led to extensive chromosome degradation and severe loss of cell viability. This cell killing was partially suppressed by chromosomal dcm and completely abolished by dcm expressed from a plasmid. Dcm, therefore, can play the role of a "molecular vaccine" by defending the genome against parasitism by a restriction-modification gene complex. | lld:pubmed |
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| pubmed-article:12399478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12399478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12399478 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12399478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12399478 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12399478 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:12399478 | pubmed:author | pubmed-author:TakahashiNori... | lld:pubmed |
| pubmed-article:12399478 | pubmed:author | pubmed-author:KobayashiIchi... | lld:pubmed |
| pubmed-article:12399478 | pubmed:author | pubmed-author:NaitoYasuhiro... | lld:pubmed |
| pubmed-article:12399478 | pubmed:author | pubmed-author:HandaNaofumiN | lld:pubmed |
| pubmed-article:12399478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12399478 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:12399478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12399478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12399478 | pubmed:pagination | 6100-8 | lld:pubmed |
| pubmed-article:12399478 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12399478 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12399478 | pubmed:articleTitle | A DNA methyltransferase can protect the genome from postdisturbance attack by a restriction-modification gene complex. | lld:pubmed |
| pubmed-article:12399478 | pubmed:affiliation | Division of Molecular Biology, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Shirokanedai, Japan. | lld:pubmed |
| pubmed-article:12399478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12399478 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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