| pubmed-article:12398838 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12398838 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12398838 | lifeskim:mentions | umls-concept:C0026848 | lld:lifeskim |
| pubmed-article:12398838 | lifeskim:mentions | umls-concept:C0441635 | lld:lifeskim |
| pubmed-article:12398838 | lifeskim:mentions | umls-concept:C0242697 | lld:lifeskim |
| pubmed-article:12398838 | lifeskim:mentions | umls-concept:C0012929 | lld:lifeskim |
| pubmed-article:12398838 | lifeskim:mentions | umls-concept:C0010749 | lld:lifeskim |
| pubmed-article:12398838 | lifeskim:mentions | umls-concept:C1444754 | lld:lifeskim |
| pubmed-article:12398838 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12398838 | pubmed:dateCreated | 2002-10-25 | lld:pubmed |
| pubmed-article:12398838 | pubmed:abstractText | Heteroplasmic mitochondrial DNA mutations often cause a skeletal myopathy associated with a mosaic distribution of cytochrome c oxidase-deficient muscle fibres. The function of an individual muscle fibre is dependent upon the metabolic activity throughout its length, but little is known about the length of cytochrome c oxidase-deficient segments in human skeletal muscle in patients with mitochondrial disease. We studied cytochrome c oxidase activity by serial section analysis of quadriceps muscle from two patients. We observed a striking variation in the length of the cytochrome c oxidase-negative segments. The shortest segments were 10 microm long, and the longest segment was the entire length of the larger biopsy (> or =1.2 mm). The lengths of the cytochrome c oxidase-negative segments were generally shorter in the less severely affected biopsy, and we frequently observed non-contiguous segments of cytochrome c oxidase deficiency within the same muscle fibre. The findings have important implications for our understanding of the pathogenesis and progression of mitochondrial DNA myopathy. | lld:pubmed |
| pubmed-article:12398838 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12398838 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12398838 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12398838 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12398838 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12398838 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12398838 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12398838 | pubmed:issn | 0960-8966 | lld:pubmed |
| pubmed-article:12398838 | pubmed:author | pubmed-author:JohnsonMargar... | lld:pubmed |
| pubmed-article:12398838 | pubmed:author | pubmed-author:TurnbullDougl... | lld:pubmed |
| pubmed-article:12398838 | pubmed:author | pubmed-author:ChinneryPatri... | lld:pubmed |
| pubmed-article:12398838 | pubmed:author | pubmed-author:ElsonJoanna... | lld:pubmed |
| pubmed-article:12398838 | pubmed:author | pubmed-author:SamuelsDavid... | lld:pubmed |
| pubmed-article:12398838 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12398838 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12398838 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12398838 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12398838 | pubmed:pagination | 858-64 | lld:pubmed |
| pubmed-article:12398838 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:meshHeading | pubmed-meshheading:12398838... | lld:pubmed |
| pubmed-article:12398838 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12398838 | pubmed:articleTitle | The length of cytochrome c oxidase-negative segments in muscle fibres in patients with mtDNA myopathy. | lld:pubmed |
| pubmed-article:12398838 | pubmed:affiliation | Department of Neurology, University of Newcastle upon Tyne, The Medical School, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK. | lld:pubmed |
| pubmed-article:12398838 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12398838 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12398838 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12398838 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:12398838 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12398838 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12398838 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12398838 | lld:pubmed |
