| pubmed-article:12392741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12392741 | lifeskim:mentions | umls-concept:C0022947 | lld:lifeskim |
| pubmed-article:12392741 | lifeskim:mentions | umls-concept:C1257954 | lld:lifeskim |
| pubmed-article:12392741 | lifeskim:mentions | umls-concept:C2350400 | lld:lifeskim |
| pubmed-article:12392741 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:12392741 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:12392741 | lifeskim:mentions | umls-concept:C1956166 | lld:lifeskim |
| pubmed-article:12392741 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:12392741 | pubmed:dateCreated | 2002-10-23 | lld:pubmed |
| pubmed-article:12392741 | pubmed:abstractText | The COX-2 inhibitor DFP [5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanone] was found to have a long half-life in humans. Analogues have been characterized in order to optimize pharmacokinetics. This has lead to the discovery of 5(S)-(5-ethyl-5-methyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanone analogue 11 a potent and selective COX-2 inhibitor which is metabolized to a greater extent than DFP upon incubation with rat and human hepatocytes, suggesting a shorter half-life in humans. | lld:pubmed |
| pubmed-article:12392741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12392741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12392741 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12392741 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:GordonRobertR | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:RiendeauDenis... | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:BrideauChrist... | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:ChanChi... | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:ChauretNathal... | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:SilvaJosé MJM | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:RoyPatrickP | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:LeblancYvesY | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:YergeyJames... | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:Nicoll-Griffi... | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:WangZhaoyinZ | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:LiChun SingCS | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:AubinYvesY | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:XuLijingL | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:WebbJanineJ | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:ViscoDenise... | lld:pubmed |
| pubmed-article:12392741 | pubmed:author | pubmed-author:PrasitPetpibo... | lld:pubmed |
| pubmed-article:12392741 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12392741 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:12392741 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12392741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12392741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12392741 | pubmed:pagination | 3317-20 | lld:pubmed |
| pubmed-article:12392741 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:meshHeading | pubmed-meshheading:12392741... | lld:pubmed |
| pubmed-article:12392741 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12392741 | pubmed:articleTitle | Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile. | lld:pubmed |
| pubmed-article:12392741 | pubmed:affiliation | Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire-Dorval, Quebec, Canada. yves_leblanc@merck.com | lld:pubmed |
| pubmed-article:12392741 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12392741 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12392741 | lld:chembl |
