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pubmed-article:12391492pubmed:abstractTextWe tested whether dispersible L-dopa has acute effects on event-related desynchronization (ERD) of the mu rhythm in patients with idiopathic Parkinson's disease (IPD). ERD to voluntary movement is delayed in akinetic IPD patients and improves after chronic L-dopa treatment. We evaluated ERD to self-paced finger movement in 14 IPD patients (before and 30-40 min after oral administration of dispersible L-dopa) and in 10 normal subjects. Sensorimotor ERD onset contralateral to movement was significantly delayed in IPD patients compared to normal subjects. This abnormality was no longer significant after L-dopa treatment. We conclude that a single dose of dispersible L-dopa can improve not only motor performance in IPD patients but also the timing of cortical activation of sensorimotor areas during motor programming.lld:pubmed
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pubmed-article:12391492pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12391492pubmed:articleTitleAcute effects of L-dopa on event-related desynchronization in Parkinson's disease.lld:pubmed
pubmed-article:12391492pubmed:affiliationDepartment of Clinical Neurophysiology, San Raffaele Scientific Institute, Milan, Italy.lld:pubmed
pubmed-article:12391492pubmed:publicationTypeJournal Articlelld:pubmed