Linked Life Data

12391138

Source:http://linkedlifedata.com/resource/pubmed/id/12391138

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pubmed-article:12391138pubmed:abstractTextEpisodic hypoxia elicits a long-lasting augmentation of phrenic inspiratory activity known as long-term facilitation (LTF). We investigated the respective contributions of carotid chemoafferent neuron activation and hypoxia to the expression of LTF in urethane-anesthetized, vagotomized, paralyzed, and ventilated Sprague-Dawley rats. One hour after three 5-min isocapnic hypoxic episodes [arterial Po(2) (Pa(O(2))) = 40 +/- 5 Torr], integrated phrenic burst amplitude was greater than baseline in both carotid-denervated (n = 8) and sham-operated (n = 7) rats (P < 0.05), indicating LTF. LTF was reduced in carotid-denervated rats relative to sham (P < 0.05). In this and previous studies, rats were ventilated with hyperoxic gas mixtures (inspired oxygen fraction = 0.5) under baseline conditions. To determine whether episodic hyperoxia induces LTF, phrenic activity was recorded under normoxic (Pa(O(2)) = 90-100 Torr) conditions before and after three 5-min episodes of isocapnic hypoxia (Pa(O(2)) = 40 +/- 5 Torr; n = 6) or hyperoxia (Pa(O(2)) > 470 Torr; n = 6). Phrenic burst amplitude was greater than baseline 1 h after episodic hypoxia (P < 0.05), but episodic hyperoxia had no detectable effect. These data suggest that hypoxia per se initiates LTF independently from carotid chemoafferent neuron activation, perhaps through direct central nervous system effects.lld:pubmed
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pubmed-article:12391138pubmed:authorpubmed-author:MitchellGordo...lld:pubmed
pubmed-article:12391138pubmed:authorpubmed-author:BavisRyan WRWlld:pubmed
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pubmed-article:12391138pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:12391138pubmed:articleTitleIntermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats.lld:pubmed
pubmed-article:12391138pubmed:affiliationDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, 53706, USA. bavisr@svm.vetmed.wisc.edulld:pubmed
pubmed-article:12391138pubmed:publicationTypeJournal Articlelld:pubmed
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