| pubmed-article:12389042 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12389042 | lifeskim:mentions | umls-concept:C1171348 | lld:lifeskim |
| pubmed-article:12389042 | lifeskim:mentions | umls-concept:C0598783 | lld:lifeskim |
| pubmed-article:12389042 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:12389042 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12389042 | pubmed:dateCreated | 2002-10-30 | lld:pubmed |
| pubmed-article:12389042 | pubmed:abstractText | T cell activation is triggered by several hours of contact with peptide-major histocompatibility (MHC) complexes on the surface of antigen-presenting cells (APCs). The nature and location of the sustained signal transduction pathways required for T cell activation are unknown. We show here that the production of phosphatidylinositol(3,4,5)triphosphate (PIP3) was dynamically sustained for hours as T cells responded to antigen. In addition, sustained elevation of PIP3 was essential for T cell proliferation. There was PIP3 accumulation in the T cell-APC contact zone and at the antipodal pole of the cell. The immune synapse is thus not the sole site of sustained signal transduction in activated T cells. | lld:pubmed |
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| pubmed-article:12389042 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12389042 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12389042 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12389042 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12389042 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12389042 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:12389042 | pubmed:author | pubmed-author:CantrellDoree... | lld:pubmed |
| pubmed-article:12389042 | pubmed:author | pubmed-author:CostelloPatri... | lld:pubmed |
| pubmed-article:12389042 | pubmed:author | pubmed-author:GallagherMaig... | lld:pubmed |
| pubmed-article:12389042 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12389042 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:12389042 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12389042 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12389042 | pubmed:pagination | 1082-9 | lld:pubmed |
| pubmed-article:12389042 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12389042 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12389042 | pubmed:articleTitle | Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. | lld:pubmed |
| pubmed-article:12389042 | pubmed:affiliation | Lymphocyte Activation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. | lld:pubmed |
| pubmed-article:12389042 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12389042 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12389042 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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