| pubmed-article:12379863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C0004461 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C2003939 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C1521902 | lld:lifeskim |
| pubmed-article:12379863 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:12379863 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12379863 | pubmed:dateCreated | 2002-10-29 | lld:pubmed |
| pubmed-article:12379863 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12379863 | pubmed:abstractText | Axons are defined by the presence of presynaptic specializations at specific locations. We show here that loss-of-function mutations in the C. elegans gene syd-1 cause presynaptic specializations to form in the dendritic processes of GABA-expressing motor neurons during initial differentiation. At a later developmental stage, however, syd-1 is not required for the polarity respecification of a subset of these neurons. The SYD-1 protein contains PDZ, C2 and rho-GTPase activating protein (GAP)-like domains, and is localized to presynaptic terminals in mature neurons. A truncated SYD-1 that lacks the rhoGAP domain interferes with neurite outgrowth and guidance. Our data indicate that syd-1 may be involved in specifying axon identity during initial polarity acquisition. | lld:pubmed |
| pubmed-article:12379863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12379863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12379863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12379863 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12379863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12379863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12379863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12379863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12379863 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12379863 | pubmed:issn | 1097-6256 | lld:pubmed |
| pubmed-article:12379863 | pubmed:author | pubmed-author:JinYishiY | lld:pubmed |
| pubmed-article:12379863 | pubmed:author | pubmed-author:BaranReneeR | lld:pubmed |
| pubmed-article:12379863 | pubmed:author | pubmed-author:HallamSteven... | lld:pubmed |
| pubmed-article:12379863 | pubmed:author | pubmed-author:GoncharovAlex... | lld:pubmed |
| pubmed-article:12379863 | pubmed:author | pubmed-author:McEwenJasonJ | lld:pubmed |
| pubmed-article:12379863 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12379863 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:12379863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12379863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12379863 | pubmed:pagination | 1137-46 | lld:pubmed |
| pubmed-article:12379863 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
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| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:meshHeading | pubmed-meshheading:12379863... | lld:pubmed |
| pubmed-article:12379863 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12379863 | pubmed:articleTitle | SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans. | lld:pubmed |
| pubmed-article:12379863 | pubmed:affiliation | Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA. | lld:pubmed |
| pubmed-article:12379863 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12379863 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12379863 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12379863 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:174230 | entrezgene:pubmed | pubmed-article:12379863 | lld:entrezgene |
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