| pubmed-article:12377407 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12377407 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:12377407 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:12377407 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:12377407 | lifeskim:mentions | umls-concept:C0205065 | lld:lifeskim |
| pubmed-article:12377407 | lifeskim:mentions | umls-concept:C0685938 | lld:lifeskim |
| pubmed-article:12377407 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12377407 | pubmed:dateCreated | 2002-10-14 | lld:pubmed |
| pubmed-article:12377407 | pubmed:abstractText | We report a multigeneration family in which hematologic cancers, particularly acute myelocytic leukemia (AML), and solid tumors were interspersed in cancer-prone lineages consistent with an autosomal dominant mode of genetic transmission. This combination of AML and solid tumors, in the absence of a known hereditary disorder such as the Li-Fraumeni syndrome, appears to be unique. This pedigree appears to support our hypothesis of a genetic susceptibility to both solid tumors and hematologic cancer in this kindred. Our study involved the genetic work-up of the family and the education of high-risk patients. Medical and pathology reports were retrieved for cross-referencing and verification of family reports. Blood collected through venipuncture and, when available, diagnostic bone marrow specimens were obtained for cytogenetic studies, inclusive of multiflour fluorescence in situ hybridization (M-FISH) and G-banding methods. Slides and tissue blocks were reviewed, when available. No constitutional chromosomal abnormality or rearrangement and no abnormal platelet count or function was identified in cancer-affected members or high-risk relatives in this family. However, two family members affected with AML exhibited abnormal acquired clones in their bone marrow specimens by both G-band studies and interphase FISH, both with a deletion of 5q. | lld:pubmed |
| pubmed-article:12377407 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12377407 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12377407 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12377407 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12377407 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12377407 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12377407 | pubmed:issn | 0165-4608 | lld:pubmed |
| pubmed-article:12377407 | pubmed:author | pubmed-author:WeisenburgerD... | lld:pubmed |
| pubmed-article:12377407 | pubmed:author | pubmed-author:LynchHenry... | lld:pubmed |
| pubmed-article:12377407 | pubmed:author | pubmed-author:SangerWarren... | lld:pubmed |
| pubmed-article:12377407 | pubmed:author | pubmed-author:LynchJane FJF | lld:pubmed |
| pubmed-article:12377407 | pubmed:author | pubmed-author:LipkinSteven... | lld:pubmed |
| pubmed-article:12377407 | pubmed:author | pubmed-author:Quinn-LaquerB... | lld:pubmed |
| pubmed-article:12377407 | pubmed:author | pubmed-author:SnyderCarrie... | lld:pubmed |
| pubmed-article:12377407 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12377407 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:12377407 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12377407 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12377407 | pubmed:pagination | 8-14 | lld:pubmed |
| pubmed-article:12377407 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:meshHeading | pubmed-meshheading:12377407... | lld:pubmed |
| pubmed-article:12377407 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12377407 | pubmed:articleTitle | Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer. | lld:pubmed |
| pubmed-article:12377407 | pubmed:affiliation | Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA. htlynch@creighton.edu | lld:pubmed |
| pubmed-article:12377407 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12377407 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12377407 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12377407 | lld:pubmed |
