| pubmed-article:12376404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12376404 | lifeskim:mentions | umls-concept:C0015967 | lld:lifeskim |
| pubmed-article:12376404 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:12376404 | lifeskim:mentions | umls-concept:C0033559 | lld:lifeskim |
| pubmed-article:12376404 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:12376404 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:12376404 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12376404 | pubmed:dateCreated | 2002-10-11 | lld:pubmed |
| pubmed-article:12376404 | pubmed:abstractText | The febrile response to lipopolysaccharide (LPS) consists of three phases (phases I-III), all requiring de novo synthesis of prostaglandin (PG) E(2). The major mechanism for activation of PGE(2)-synthesizing enzymes is transcriptional upregulation. The triphasic febrile response of Wistar-Kyoto rats to intravenous LPS (50 microg/kg) was studied. Using real-time RT-PCR, the expression of seven PGE(2)-synthesizing enzymes in the LPS-processing organs (liver and lungs) and the brain "febrigenic center" (hypothalamus) was quantified. Phase I involved transcriptional upregulation of the functionally coupled cyclooxygenase (COX)-2 and microsomal (m) PGE synthase (PGES) in the liver and lungs. Phase II entailed robust upregulation of all enzymes of the major inflammatory pathway, i.e., secretory (s) phospholipase (PL) A(2)-IIA --> COX-2 --> mPGES, in both the periphery and brain. Phase III was accompanied by the induction of cytosolic (c) PLA(2)-alpha in the hypothalamus, further upregulation of sPLA(2)-IIA and mPGES in the hypothalamus and liver, and a decrease in the expression of COX-1 and COX-2 in all tissues studied. Neither sPLA(2)-V nor cPGES was induced by LPS. The high magnitude of upregulation of mPGES and sPLA(2)-IIA (1,257-fold and 133-fold, respectively) makes these enzymes attractive targets for anti-inflammatory therapy. | lld:pubmed |
| pubmed-article:12376404 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12376404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12376404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12376404 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12376404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12376404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12376404 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12376404 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:12376404 | pubmed:author | pubmed-author:IvanovAndrei... | lld:pubmed |
| pubmed-article:12376404 | pubmed:author | pubmed-author:RomanovskyAnd... | lld:pubmed |
| pubmed-article:12376404 | pubmed:author | pubmed-author:PeroRalph SRS | lld:pubmed |
| pubmed-article:12376404 | pubmed:author | pubmed-author:ScheckAdrienn... | lld:pubmed |
| pubmed-article:12376404 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12376404 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:12376404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12376404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12376404 | pubmed:pagination | R1104-17 | lld:pubmed |
| pubmed-article:12376404 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12376404 | pubmed:meshHeading | pubmed-meshheading:12376404... | lld:pubmed |
| pubmed-article:12376404 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12376404 | pubmed:articleTitle | Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation. | lld:pubmed |
| pubmed-article:12376404 | pubmed:affiliation | Trauma Research, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA. | lld:pubmed |
| pubmed-article:12376404 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12376404 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12376404 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:59103 | entrezgene:pubmed | pubmed-article:12376404 | lld:entrezgene |
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