| pubmed-article:12372597 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C1417014 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C1418406 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C0332282 | lld:lifeskim |
| pubmed-article:12372597 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12372597 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:12372597 | pubmed:dateCreated | 2002-10-9 | lld:pubmed |
| pubmed-article:12372597 | pubmed:abstractText | ALG-2 (apoptosis linked gene-2) is an essential protein for the execution of apoptosis whose function is largely unknown. Here, we demonstrate that ALG-2 could interact with the C-terminus (amino acids 941-1375) of the apoptosis signal-regulating kinase 1 (ASK1) in BOSC23 cells as well as in vitro. ASK1 failed to bind to an isotype of ALG-2 found in the liver, ALG-2,1, in which two amino acids (Gly-121 and Phe-122) are deleted. This implies that the interaction is very specific. Cotransfection with ALG-2 resulted in the nuclear presence of ASK1 and inhibited the activation of c-Jun N-terminal kinase (JNK) by ASK1 in BOSC23 cells. This study reports that ALG-2 could regulate the subcellular localization and the JNK activity modulation of ASK1 by direct interaction. | lld:pubmed |
| pubmed-article:12372597 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12372597 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12372597 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12372597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12372597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12372597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12372597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12372597 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12372597 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12372597 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:12372597 | pubmed:author | pubmed-author:KimEunheeE | lld:pubmed |
| pubmed-article:12372597 | pubmed:author | pubmed-author:HwangIn-SikIS | lld:pubmed |
| pubmed-article:12372597 | pubmed:author | pubmed-author:JungYong-SamY... | lld:pubmed |
| pubmed-article:12372597 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12372597 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:12372597 | pubmed:volume | 529 | lld:pubmed |
| pubmed-article:12372597 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12372597 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12372597 | pubmed:pagination | 183-7 | lld:pubmed |
| pubmed-article:12372597 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:meshHeading | pubmed-meshheading:12372597... | lld:pubmed |
| pubmed-article:12372597 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12372597 | pubmed:articleTitle | Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation. | lld:pubmed |
| pubmed-article:12372597 | pubmed:affiliation | Research Center for Biomedicinal Resources and Division of Life Science, PaiChai University, 439-6 Doma-2-dong, Seo-gu, Taejon 302-735, South Korea. | lld:pubmed |
| pubmed-article:12372597 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12372597 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| entrez-gene:10016 | entrezgene:pubmed | pubmed-article:12372597 | lld:entrezgene |
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