| pubmed-article:12370512 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12370512 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12370512 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:12370512 | lifeskim:mentions | umls-concept:C0033105 | lld:lifeskim |
| pubmed-article:12370512 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:12370512 | lifeskim:mentions | umls-concept:C0121925 | lld:lifeskim |
| pubmed-article:12370512 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:12370512 | pubmed:dateCreated | 2002-10-8 | lld:pubmed |
| pubmed-article:12370512 | pubmed:abstractText | The K65R mutation in HIV-1 reverse transcriptase is associated with reduced susceptibility to abacavir and tenofovir. We established its prevalence within a large clinical database, and investigated correlations with other resistance-associated mutations and antiretroviral history. The presence of K65R is associated with previous abacavir use. Although rare, it is preferentially selected within non-thymidine analogue-containing regimens, compared with concurrent zidovudine or stavudine use, which is associated with thymidine analogue mutations. Both genetic routes may compromise abacavir and tenofovir activity. | lld:pubmed |
| pubmed-article:12370512 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12370512 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12370512 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12370512 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12370512 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12370512 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12370512 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12370512 | pubmed:issn | 0269-9370 | lld:pubmed |
| pubmed-article:12370512 | pubmed:author | pubmed-author:MandaliaSundh... | lld:pubmed |
| pubmed-article:12370512 | pubmed:author | pubmed-author:PillayDeenanD | lld:pubmed |
| pubmed-article:12370512 | pubmed:author | pubmed-author:WinstonAlanA | lld:pubmed |
| pubmed-article:12370512 | pubmed:author | pubmed-author:GazzardBrianB | lld:pubmed |
| pubmed-article:12370512 | pubmed:author | pubmed-author:PozniakAntonA | lld:pubmed |
| pubmed-article:12370512 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12370512 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:12370512 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:12370512 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12370512 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12370512 | pubmed:pagination | 2087-9 | lld:pubmed |
| pubmed-article:12370512 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12370512 | pubmed:meshHeading | pubmed-meshheading:12370512... | lld:pubmed |
| pubmed-article:12370512 | pubmed:meshHeading | pubmed-meshheading:12370512... | lld:pubmed |
| pubmed-article:12370512 | pubmed:meshHeading | pubmed-meshheading:12370512... | lld:pubmed |
| pubmed-article:12370512 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12370512 | pubmed:articleTitle | The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovir-naive patients. | lld:pubmed |
| pubmed-article:12370512 | pubmed:affiliation | Department of Genitourinary/HIV Medicine, Chelsea and Westminster Hospital, London, UK. | lld:pubmed |
| pubmed-article:12370512 | pubmed:publicationType | Journal Article | lld:pubmed |
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