| pubmed-article:12368501 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12368501 | lifeskim:mentions | umls-concept:C1138842 | lld:lifeskim |
| pubmed-article:12368501 | lifeskim:mentions | umls-concept:C0242772 | lld:lifeskim |
| pubmed-article:12368501 | lifeskim:mentions | umls-concept:C0812327 | lld:lifeskim |
| pubmed-article:12368501 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:12368501 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12368501 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12368501 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12368501 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12368501 | pubmed:dateCreated | 2002-10-7 | lld:pubmed |
| pubmed-article:12368501 | pubmed:abstractText | Flavonoids are a group of polyphenolic plant secondary metabolites important for plant biology and human nutrition. In particular flavonols are potent antioxidants, and their dietary intake is correlated with a reduced risk of cardiovascular diseases. Tomato fruit contain only in their peel small amounts of flavonoids, mainly naringenin chalcone and the flavonol rutin, a quercetin glycoside. To increase flavonoid levels in tomato, we expressed the maize transcription factor genes LC and C1 in the fruit of genetically modified tomato plants. Expression of both genes was required and sufficient to upregulate the flavonoid pathway in tomato fruit flesh, a tissue that normally does not produce any flavonoids. These fruit accumulated high levels of the flavonol kaempferol and, to a lesser extent, the flavanone naringenin in their flesh. All flavonoids detected were present as glycosides. Anthocyanins, previously reported to accumulate upon LC expression in several plant species, were present in LC/C1 tomato leaves but could not be detected in ripe LC/C1 fruit. RNA expression analysis of ripening fruit revealed that, with the exception of chalcone isomerase, all of the structural genes required for the production of kaempferol-type flavonols and pelargonidin-type anthocyanins were induced strongly by the LC/C1 transcription factors. Expression of the genes encoding flavanone-3'-hydroxylase and flavanone-3'5'-hydroxylase, which are required for the modification of B-ring hydroxylation patterns, was not affected by LC/C1. Comparison of flavonoid profiles and gene expression data between tomato leaves and fruit indicates that the absence of anthocyanins in LC/C1 fruit is attributable primarily to an insufficient expression of the gene encoding flavanone-3'5'-hydroxylase, in combination with a strong preference of the tomato dihydroflavonol reductase enzyme to use the flavanone-3'5'-hydroxylase reaction product dihydromyricetin as a substrate. | lld:pubmed |
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| pubmed-article:12368501 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12368501 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12368501 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12368501 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12368501 | pubmed:issn | 1040-4651 | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:RobinsonSueS | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:VerhoeyenMart... | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:Santos-Buelga... | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:BovyArnaudA | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:de VosRicR | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:KemperMarkM | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:SchijlenElioE | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:Almenar... | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:MuirShelaghS | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:CollinsGeoffG | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:HughesSteveS | lld:pubmed |
| pubmed-article:12368501 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:12368501 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12368501 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:12368501 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12368501 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12368501 | pubmed:pagination | 2509-26 | lld:pubmed |
| pubmed-article:12368501 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
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| pubmed-article:12368501 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12368501 | pubmed:articleTitle | High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and C1. | lld:pubmed |
| pubmed-article:12368501 | pubmed:affiliation | Plant Research International, Droevendaalsesteeg 1, P.O. Box 16, 6700 AA Wageningen, The Netherlands. a.g.bovy@plant.wag-ur.nl | lld:pubmed |
| pubmed-article:12368501 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12368501 | pubmed:publicationType | Comparative Study | lld:pubmed |
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