| pubmed-article:12368266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C1948062 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C0754910 | lld:lifeskim |
| pubmed-article:12368266 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:12368266 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:12368266 | pubmed:dateCreated | 2002-10-7 | lld:pubmed |
| pubmed-article:12368266 | pubmed:abstractText | Transcription activation by the Escherichia coli cyclic AMP receptor protein (CRP) at different promoters has been studied using RNA polymerase holoenzyme derivatives containing two full-length alpha subunits, or containing one full-length alpha subunit and one truncated alpha subunit lacking the alpha C-terminal domain (alpha CTD). At a promoter having a single DNA site for CRP, activation requires only one full-length alpha subunit. Likewise, at a promoter having a single DNA site for CRP and one adjacent UP-element subsite (high-affinity DNA site for alpha CTD), activation requires only one full-length alpha subunit. In contrast, at promoters having two DNA sites for CRP, or one DNA site for CRP and two UP-element subsites, activation requires two full-length alpha subunits. We conclude that a single copy of alpha CTD is sufficient to interact with one CRP molecule and one adjacent UP-element subsite, but two copies of alpha CTD are required to interact with two CRP molecules or with one CRP molecule and two UP-element subsites. | lld:pubmed |
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| pubmed-article:12368266 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12368266 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12368266 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12368266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12368266 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12368266 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:12368266 | pubmed:author | pubmed-author:SakL PLP | lld:pubmed |
| pubmed-article:12368266 | pubmed:author | pubmed-author:EbrightRichar... | lld:pubmed |
| pubmed-article:12368266 | pubmed:author | pubmed-author:LloydGeorgina... | lld:pubmed |
| pubmed-article:12368266 | pubmed:author | pubmed-author:BusbyStephen... | lld:pubmed |
| pubmed-article:12368266 | pubmed:author | pubmed-author:TebbuttJohnJ | lld:pubmed |
| pubmed-article:12368266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12368266 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12368266 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:12368266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12368266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12368266 | pubmed:pagination | 2557-65 | lld:pubmed |
| pubmed-article:12368266 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12368266 | pubmed:meshHeading | pubmed-meshheading:12368266... | lld:pubmed |
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| pubmed-article:12368266 | pubmed:meshHeading | pubmed-meshheading:12368266... | lld:pubmed |
| pubmed-article:12368266 | pubmed:meshHeading | pubmed-meshheading:12368266... | lld:pubmed |
| pubmed-article:12368266 | pubmed:meshHeading | pubmed-meshheading:12368266... | lld:pubmed |
| pubmed-article:12368266 | pubmed:meshHeading | pubmed-meshheading:12368266... | lld:pubmed |
| pubmed-article:12368266 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12368266 | pubmed:articleTitle | Requirement for two copies of RNA polymerase alpha subunit C-terminal domain for synergistic transcription activation at complex bacterial promoters. | lld:pubmed |
| pubmed-article:12368266 | pubmed:affiliation | School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. | lld:pubmed |
| pubmed-article:12368266 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12368266 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12368266 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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