| pubmed-article:12367562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12367562 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:12367562 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:12367562 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:12367562 | lifeskim:mentions | umls-concept:C0149530 | lld:lifeskim |
| pubmed-article:12367562 | lifeskim:mentions | umls-concept:C0748972 | lld:lifeskim |
| pubmed-article:12367562 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:12367562 | pubmed:dateCreated | 2002-10-7 | lld:pubmed |
| pubmed-article:12367562 | pubmed:abstractText | It was recently reported that sera from patients with systemic lupus erythematosus contain antibodies reactive with the second extracellular loop of the serotoninergic 5-HT(4) receptor expressed in the human heart. This antibody response was associated with antibodies to 52kD SSA/Ro, a reactivity prevalent in mothers of children with congenital heart block (CHB). The current study was undertaken to determine whether the 5-HT(4) receptor is a target of the immune response in these mothers. Initial experiments demonstrated mRNA expression of the 5-HT(4) receptor in the human foetal atrium. Electrophysiologic studies established that human foetal atrial cells express functional 5-HT(4) receptors. Sera from 116 mothers enrolled in the Research Registry for Neonatal Lupus, whose children have CHB, were evaluated. Ninety-nine (85%) of these maternal sera contained antibodies to SSA/Ro, 84% of which were reactive with the 52kD SSA/Ro component by immunoblot. None of the 116 sera were reactive with the peptide spanning aa165-185 of the serotoninergic receptor. Rabbit antisera which recognized this peptide did not react with 52kD SSA/Ro or peptide aa365-382 in the C terminus. Although 5-HT(4) receptors are present and functional in the human foetal heart, maternal antibodies to the 5-HT(4) receptor are not associated with the development of CHB. | lld:pubmed |
| pubmed-article:12367562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12367562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12367562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12367562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12367562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12367562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12367562 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12367562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12367562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12367562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12367562 | pubmed:issn | 0896-8411 | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:BuyonJill PJP | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:AskanaseAnca... | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:Miranda-Carus... | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:ChanEdward... | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:YueYuankunY | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:ClancyRobertR | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:GarciaJoanneJ | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:QuYongxiaY | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:HuKeliK | lld:pubmed |
| pubmed-article:12367562 | pubmed:author | pubmed-author:BoutjdirMoham... | lld:pubmed |
| pubmed-article:12367562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12367562 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:12367562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12367562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12367562 | pubmed:pagination | 79-86 | lld:pubmed |
| pubmed-article:12367562 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:meshHeading | pubmed-meshheading:12367562... | lld:pubmed |
| pubmed-article:12367562 | pubmed:articleTitle | Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block. | lld:pubmed |
| pubmed-article:12367562 | pubmed:affiliation | Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA. jill.buyon@med.nyu.edu | lld:pubmed |
| pubmed-article:12367562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12367562 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12367562 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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