The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms.

Source:http://linkedlifedata.com/resource/pubmed/id/12353144

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Authors

Horinouchi M, Yonezawa S, Nakamura A, Sato E

Affiliation

Second Department of Pathology, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.

Abstract

Mucins are high molecular weight glycoproteins that have oligosaccharides attached to the apomucin protein backbone by O-glycosidic linkages. Here, we report the expression of MUC1 mucin (membrane-bound mucin), MUC2 mucin (intestinal-type secretory mucin), and MUC5AC mucin (gastric-type secretory mucin) in invasive ductal carcinomas (IDCs; n = 46) and intraductal papillary-mucinous neoplasms (IPMNs; n = 33) of the pancreas, and the relationship of this expression with malignant potential.

PMID
12353144