| pubmed-article:12297301 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12297301 | lifeskim:mentions | umls-concept:C1416562 | lld:lifeskim |
| pubmed-article:12297301 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:12297301 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:12297301 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:12297301 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:12297301 | pubmed:dateCreated | 2002-9-25 | lld:pubmed |
| pubmed-article:12297301 | pubmed:abstractText | Kv4.3 encodes the pore-forming subunit of the cardiac transient outward potassium current (I(to)). hKv4.3-encoded current does not fully replicate cardiac I(to), suggesting a functionally significant role for accessory subunits. KChIP2 associates with Kv4.3 and modifies hKv4.3-encoded currents but does not replicate native I(to). We examined the effect of several ancillary subunits expressed in the heart on hKv4.3-encoded currents. Remarkably, the ancillary subunits Kvbeta(3), minK, MiRP-1, the Na channel beta(1) and KChIP2 increased the density and modified the gating of hKv4.3 current. hKv4.3 promiscuously assembles with ancillary subunits in vitro, functionally modifying the encoded currents; however, the physiological significance is uncertain. | lld:pubmed |
| pubmed-article:12297301 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12297301 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12297301 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12297301 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12297301 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12297301 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:12297301 | pubmed:author | pubmed-author:TomaselliGord... | lld:pubmed |
| pubmed-article:12297301 | pubmed:author | pubmed-author:DeschênesIsab... | lld:pubmed |
| pubmed-article:12297301 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12297301 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:12297301 | pubmed:volume | 528 | lld:pubmed |
| pubmed-article:12297301 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12297301 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12297301 | pubmed:pagination | 183-8 | lld:pubmed |
| pubmed-article:12297301 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12297301 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12297301 | pubmed:articleTitle | Modulation of Kv4.3 current by accessory subunits. | lld:pubmed |
| pubmed-article:12297301 | pubmed:affiliation | Department of Medicine, Institute of Molecular Cardiobiology, Division of Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:12297301 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12297301 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12297301 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12297301 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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