| pubmed-article:12270170 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0022634 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0284930 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0449444 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12270170 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12270170 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:12270170 | pubmed:dateCreated | 2002-9-24 | lld:pubmed |
| pubmed-article:12270170 | pubmed:abstractText | Cathepsin K is highly expressed in human osteoclasts, and is implicated in bone resorption. This makes it an attractive target for the treatment of osteoporosis. Peptides containing 2-amino-1'-hydroxymethyl ketones and 2-amino-1'-alkoxymethyl ketones were discovered as potent inhibitors of cathepsin K. A novel synthetic route was devised to facilitate rapid elucidation of the SAR of these inhibitors. The synthesis and SAR of hydroxymethyl ketones are presented. | lld:pubmed |
| pubmed-article:12270170 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12270170 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12270170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12270170 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12270170 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12270170 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12270170 | pubmed:author | pubmed-author:PalmerJames... | lld:pubmed |
| pubmed-article:12270170 | pubmed:author | pubmed-author:MendoncaRohan... | lld:pubmed |
| pubmed-article:12270170 | pubmed:author | pubmed-author:VenkatramanSh... | lld:pubmed |
| pubmed-article:12270170 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12270170 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:12270170 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12270170 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12270170 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12270170 | pubmed:pagination | 2887-91 | lld:pubmed |
| pubmed-article:12270170 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:meshHeading | pubmed-meshheading:12270170... | lld:pubmed |
| pubmed-article:12270170 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12270170 | pubmed:articleTitle | Novel route to the synthesis of peptides containing 2-amino-1'-hydroxymethyl ketones and their application as cathepsin K inhibitors. | lld:pubmed |
| pubmed-article:12270170 | pubmed:affiliation | Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. rohan.mendonca@celera.com | lld:pubmed |
| pubmed-article:12270170 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12270170 | lld:chembl |
