| pubmed-article:12244299 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C0074512 | lld:lifeskim |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C0000657 | lld:lifeskim |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:12244299 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12244299 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12244299 | pubmed:dateCreated | 2002-9-27 | lld:pubmed |
| pubmed-article:12244299 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244299 | pubmed:abstractText | The eukaryotic signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein particle that targets secretory and membrane proteins to the endoplasmic reticulum. The binding of SRP54 to the S domain of 7SL RNA is highly dependent on SRP19. Here we present the crystal structure of a human SRP ternary complex consisting of SRP19, the M domain of SRP54 and the S domain of 7SL RNA. Upon binding of the M domain of SRP54 to the 7SL RNA-SRP19 complex, the asymmetric loop of helix 8 in 7SL RNA collapses. The bases of the four nucleotides in the long strand of the asymmetric loop continuously stack and interact with the M domain, whereas the two adenines in the short strand flip out and form two A-minor motifs with helix 6. This stabilizing interaction is only possible when helix 6 has been positioned parallel to helix 8 by the prior binding of SRP19 to the tetraloops of helices 6 and 8. Hence, the crystal structure of the ternary complex suggests why SRP19 is necessary for the stable binding of SRP54 to the S domain RNA. | lld:pubmed |
| pubmed-article:12244299 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244299 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12244299 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244299 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12244299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12244299 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12244299 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12244299 | pubmed:issn | 1072-8368 | lld:pubmed |
| pubmed-article:12244299 | pubmed:author | pubmed-author:OubridgeChris... | lld:pubmed |
| pubmed-article:12244299 | pubmed:author | pubmed-author:KuglstatterAn... | lld:pubmed |
| pubmed-article:12244299 | pubmed:author | pubmed-author:NagaiKiyoshiK | lld:pubmed |
| pubmed-article:12244299 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12244299 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12244299 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12244299 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12244299 | pubmed:pagination | 740-4 | lld:pubmed |
| pubmed-article:12244299 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12244299 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12244299 | pubmed:articleTitle | Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. | lld:pubmed |
| pubmed-article:12244299 | pubmed:affiliation | MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. | lld:pubmed |
| pubmed-article:12244299 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12244299 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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