Linked Life Data

12243864

Source:http://linkedlifedata.com/resource/pubmed/id/12243864

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pubmed-article:12243864pubmed:abstractTextTopical exposure to permethrin has often been implicated as a mitigating factor in the illnesses reported in Gulf War veterans. These studies were designed to assess the effect of co-exposure to low level sulfur mustard, JP-8 jet fuel, N,N-diethyl-m-toluamide (DEET) and fabric occlusion on the percutaneous absorption and skin disposition of topically applied 14C-permethrin (40 microg/cm(2)) in the isolated perfused porcine skin flap (IPPSF) model. Extent of dermal absorption in vehicle controls in the IPPSF was comparable to literature values for humans. These studies demonstrated a two-fold increased 14C-permethrin percutaneous absorption and almost three-fold increased penetration when JP-8 was present, compared to a one-third decreased permethrin flux in the presence of sulfur mustard. Complete occlusion slightly increased 14C-permethrin absorption, while occlusion with fabric showed no significant effect. A previously noted effect of DEET to inhibit permethrin absorption was still seen in the presence of sulfur mustard exposure. These studies suggest that co-exposure to JP-8 or sulfur mustard may modulate transdermal flux of 14C-permethrin. However, the JP-8 increase in absorption and penetration was less than the five-fold increase previously seen with arterial infusion of pyridostigmine bromide and diisopropylfluorophosphate in the IPPSF. The toxicologic significance of this moderate increase in permethrin absorption remains unclear.lld:pubmed
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pubmed-article:12243864pubmed:authorpubmed-author:RiviereJim...lld:pubmed
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pubmed-article:12243864pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12243864pubmed:articleTitleGulf War related exposure factors influencing topical absorption of 14C-permethrin.lld:pubmed
pubmed-article:12243864pubmed:affiliationCenter for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA. jim_riviere@ncsu.edulld:pubmed
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