| pubmed-article:12239302 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12239302 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12239302 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:12239302 | pubmed:dateCreated | 2002-9-19 | lld:pubmed |
| pubmed-article:12239302 | pubmed:abstractText | CD8(+) cytotoxic T lymphocytes (CTLs) are now recognized as important mediators of immunity against intracellular pathogens, including human immunodeficiency virus and tumors. How to efficiently evoke antigen-specific CTL responses in vivo has become a crucial problem in the development of modern vaccines. Here, we developed a completely novel CTL vaccine-mimovirus, which is a kind of virus-size particulate antigen delivery system. It was formed by the self-assembly of a cationic peptide containing 18 lysines and a CTL-epitope peptide of HBsAg(28-39), with a plasmid encoding mouse interleukin-12 (IL-12) through electrostatic interactions. We examined the formation of mimovirus by DNA retardation assay, DNase I protection assay, and transmission electron microscopy and demonstrated that mimovirus could efficiently transfer the plasmid encoding IL-12 into mammalian cells such as P815 cells in vitro. Furthermore, it was proved that mimovirus could induce an HBsAg(28-39)-specific CTL response in vivo. Considering its effectiveness, flexibility, and defined composition, mimovirus is potentially a novel system for vaccination against intracellular pathogens and tumors. | lld:pubmed |
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| pubmed-article:12239302 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12239302 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12239302 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12239302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12239302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12239302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12239302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12239302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12239302 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12239302 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12239302 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:BianJiangJ | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:ZhouWeiW | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:WanYingY | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:WuYu-ZhangYZ | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:JiaZheng-CaiZ... | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:TangYanY | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:ZhaoJian-Ping... | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:NiBingB | lld:pubmed |
| pubmed-article:12239302 | pubmed:author | pubmed-author:ZouLi-YunLY | lld:pubmed |
| pubmed-article:12239302 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12239302 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:12239302 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12239302 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12239302 | pubmed:pagination | 10264-9 | lld:pubmed |
| pubmed-article:12239302 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
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| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
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| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
| pubmed-article:12239302 | pubmed:meshHeading | pubmed-meshheading:12239302... | lld:pubmed |
| pubmed-article:12239302 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12239302 | pubmed:articleTitle | Mimovirus: a novel form of vaccine that induces hepatitis B virus-specific cytotoxic T-lymphocyte responses in vivo. | lld:pubmed |
| pubmed-article:12239302 | pubmed:affiliation | Institute of Immunology, Third Military Medical University, Ave. Gaotanyan 30th, District Shapingba, Chongqing 400038, People's Republic of China. | lld:pubmed |
| pubmed-article:12239302 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12239302 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
