Linked Life Data

12237539

Source:http://linkedlifedata.com/resource/pubmed/id/12237539

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pubmed-article:12237539pubmed:abstractTextGeneralization of the release process through the wax matrix layer was examined by use of a reservoir device tablet. The wax matrix layer of the reservoir device tablet was prepared from a physical mixture of lactose and hydrogenated castor oil to simplify the release properties. Release through the wax matrix layer showed zero-order kinetics in a steady state after a given lag time, and could be divided into two stages. The first stage was the formation process of water channel by dissolving the soluble component in the wax matrix layer. The lag time obtained by applying the square root law equation was well connected with the amount of the matrix layer and mixed weight ratio of components in this layer. The second stage was the zero-order release process of drug in the reservoir through the wax matrix layer, because the effective surface area was fixed. The release rate constants were connected with thickness of the matrix layer and permeability coefficient, and the permeability coefficients were connected with the diffusion coefficient of drug and porosity. Hence the release rate constant could be connected with the amount of matrix layer and the mixed weight ratio of components in the matrix layer. It was therefore suggested that the release process could be generalized using the amount of matrix layer and the mixed weight ratio of components in the matrix layer.lld:pubmed
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pubmed-article:12237539pubmed:authorpubmed-author:YonezawaYorin...lld:pubmed
pubmed-article:12237539pubmed:authorpubmed-author:IshidaSumioSlld:pubmed
pubmed-article:12237539pubmed:authorpubmed-author:SuzukiShinobu...lld:pubmed
pubmed-article:12237539pubmed:authorpubmed-author:SunadaHisakaz...lld:pubmed
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pubmed-article:12237539pubmed:pagination1219-22lld:pubmed
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pubmed-article:12237539pubmed:articleTitleRelease from or through a wax matrix system. IV. Generalized expression of the release process for a reservoir device tablet.lld:pubmed
pubmed-article:12237539pubmed:affiliationFaculty of Pharmacy, Meijo University, Nagoya, Japan. yzw@ccmfs.meijo-u.ac.jplld:pubmed
pubmed-article:12237539pubmed:publicationTypeJournal Articlelld:pubmed