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pubmed-article:12232474pubmed:abstractTextWe describe a toxic multinodular goiter that was subjected to genomic sequencing of the thyroid-stimulating hormone receptor and the alpha-subunit of the stimulatory guanine nucleotide-binding protein. No mutation was detected in either gene. While frequent occurrence of thyroid-stimulating hormone receptor gene mutations in toxic multinodular goiters has been reported in areas such as part of Europe with a relatively high prevalence of iodine deficiency, toxic multinodular goiters in areas with an abundance of dietary iodine such as Japan seem unlikely to involve mutations of this gene.lld:pubmed
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pubmed-article:12232474pubmed:authorpubmed-author:TanakaHiroshi...lld:pubmed
pubmed-article:12232474pubmed:authorpubmed-author:KitanoHiroyaHlld:pubmed
pubmed-article:12232474pubmed:authorpubmed-author:TakeuchiEijiElld:pubmed
pubmed-article:12232474pubmed:authorpubmed-author:HanamitsuMasa...lld:pubmed
pubmed-article:12232474pubmed:authorpubmed-author:KitanishiTsuy...lld:pubmed
pubmed-article:12232474pubmed:authorpubmed-author:SakuraiHirono...lld:pubmed
pubmed-article:12232474pubmed:copyrightInfoCopyright 2002 S. Karger AG, Basellld:pubmed
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pubmed-article:12232474pubmed:volume64lld:pubmed
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pubmed-article:12232474pubmed:pagination275-7lld:pubmed
pubmed-article:12232474pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:12232474pubmed:articleTitleLack of reported mutations in a Japanese case of toxic multinodular goiter.lld:pubmed
pubmed-article:12232474pubmed:affiliationDepartment of Otolaryngology, Division of Head and Neck Surgery, Shiga University of Medical Science, Otsu, Japan. hanamitu@belle.shiga-med.ac.jplld:pubmed
pubmed-article:12232474pubmed:publicationTypeJournal Articlelld:pubmed
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