| pubmed-article:12231622 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C0212694 | lld:lifeskim |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C0600499 | lld:lifeskim |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C0813988 | lld:lifeskim |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:12231622 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12231622 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:12231622 | pubmed:dateCreated | 2002-9-16 | lld:pubmed |
| pubmed-article:12231622 | pubmed:abstractText | Nonhomologous end-joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks (DSBs) in mammalian cells. The DNA-dependent protein kinase (DNA-PK), consisting of Ku and DNA-PK catalytic subunit (DNA-PKcs), is activated by DNA in vitro and is required for NHEJ. We report that DNA-PKcs is autophosphorylated at Thr2609 in vivo in a Ku-dependent manner in response to ionizing radiation. Phosphorylated DNA-PKcs colocalizes with both gamma-H2AX and 53BP1 after DNA damage. Mutation of Thr2609 to Ala leads to radiation sensitivity and impaired DSB rejoining. These findings establish that Ku-dependent phosphorylation of DNA-PKcs at Thr2609 is required for the repair of DSBs by NHEJ. | lld:pubmed |
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| pubmed-article:12231622 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12231622 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12231622 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12231622 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12231622 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:12231622 | pubmed:author | pubmed-author:JinS GSG | lld:pubmed |
| pubmed-article:12231622 | pubmed:author | pubmed-author:ChenDavid JDJ | lld:pubmed |
| pubmed-article:12231622 | pubmed:author | pubmed-author:KurimasaAkihi... | lld:pubmed |
| pubmed-article:12231622 | pubmed:author | pubmed-author:ChanDoug WDW | lld:pubmed |
| pubmed-article:12231622 | pubmed:author | pubmed-author:ChenBenjamin... | lld:pubmed |
| pubmed-article:12231622 | pubmed:author | pubmed-author:Prithivirajsi... | lld:pubmed |
| pubmed-article:12231622 | pubmed:author | pubmed-author:StoryMichael... | lld:pubmed |
| pubmed-article:12231622 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12231622 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12231622 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:12231622 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12231622 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12231622 | pubmed:pagination | 2333-8 | lld:pubmed |
| pubmed-article:12231622 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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