| pubmed-article:12228277 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12228277 | lifeskim:mentions | umls-concept:C0023270 | lld:lifeskim |
| pubmed-article:12228277 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:12228277 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12228277 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12228277 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12228277 | pubmed:dateCreated | 2002-9-13 | lld:pubmed |
| pubmed-article:12228277 | pubmed:abstractText | It is widely accepted that a strong Th2 response is responsible for nonhealing Leishmania major infections in BALB/c mice. This Th2 response has been thoroughly documented by measuring the levels of Th2 cytokines produced by CD4(+) T cells present in the lymphoid organs by enzyme-linked immunosorbent assay and PCR. However, the cytokine profile of L. major-specific Th2 cells has never been determined. In this study, we used the recently described Th2 marker T1/ST2 to characterize Th2 cells during the course of nonhealing L. major infection. We analyzed the intracellular cytokine profile of CD4(+) T1/ST2(+) T cells and showed that they clearly displayed a Th2 phenotype, as they expressed interleukin 4 (IL-4), IL-10, and IL-5. In addition, we detected another population of Th2 cells among the CD4(+) T1/ST2(-) T cells that expressed IL-4 and IL-10 but excluded IL-5. In summary, we show here that two type 2 subpopulations are present in the lymphoid organs of L. major-infected BALB/c mice; Th2 cells from both subsets expressed IL-4 and IL-10, but they could be distinguished by their expression of IL-5 and T1/ST2. | lld:pubmed |
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| pubmed-article:12228277 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12228277 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12228277 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12228277 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12228277 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12228277 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:12228277 | pubmed:author | pubmed-author:KropfPascaleP | lld:pubmed |
| pubmed-article:12228277 | pubmed:author | pubmed-author:HerathShantiS | lld:pubmed |
| pubmed-article:12228277 | pubmed:author | pubmed-author:KlemenzRomanR | lld:pubmed |
| pubmed-article:12228277 | pubmed:author | pubmed-author:MüllerIngridI | lld:pubmed |
| pubmed-article:12228277 | pubmed:author | pubmed-author:TewariRitaR | lld:pubmed |
| pubmed-article:12228277 | pubmed:author | pubmed-author:SyedNeloferN | lld:pubmed |
| pubmed-article:12228277 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12228277 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:12228277 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12228277 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12228277 | pubmed:pagination | 5512-20 | lld:pubmed |
| pubmed-article:12228277 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12228277 | pubmed:meshHeading | pubmed-meshheading:12228277... | lld:pubmed |
| pubmed-article:12228277 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12228277 | pubmed:articleTitle | Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. | lld:pubmed |
| pubmed-article:12228277 | pubmed:affiliation | Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom. | lld:pubmed |
| pubmed-article:12228277 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12228277 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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