| pubmed-article:12225635 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C1556094 | lld:lifeskim |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C0677607 | lld:lifeskim |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:12225635 | lifeskim:mentions | umls-concept:C0678951 | lld:lifeskim |
| pubmed-article:12225635 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12225635 | pubmed:dateCreated | 2002-9-12 | lld:pubmed |
| pubmed-article:12225635 | pubmed:abstractText | Cytotoxic T-lymphocyte antigen-4 (CTLA-4) decreases the immune response of T cells by inactivating the signal that occurs with interaction between CD28 on T cells and B7 on antigen-presenting cells. Gene polymorphisms involving CTLA-4 promoter (-318 C/T), exon 1 (49 A/G), and exon 4 (microsatellite (AT)n) have been linked to Hashimoto's thyroiditis (HT) and other autoimmune diseases. HT also has a reported association with human T-cell lymphotrophic virus-1 (HTLV-1) infection. We investigated the occurrence of CTLA-4 polymorphisms in Japanese patients with HT with and without anti-HTLV-1 antibodies (HTLV-1 Ab). DNA samples from 143 patients with HT and 199 controls were subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis using the restriction enzymes, Bbv 1, Tse 1, and Mse 1. In the HTLV-1 Ab-positive group the exon 1 G allele was more frequent in patients with HT than in controls (67% vs. 53%, p = 0.0377), and in HTLV-1 Ab-negative group it was also frequent in patients with HT than in controls (68% vs. 53%, p = 0.0041). Frequency of the G allele in HT with HTLV-1 Ab was comparable to those without HTLV-1 Ab. Frequency of polymorphism in the promoter did not differ between patients with HT and controls, nor between controls with and without HTLV-1 Ab. HTLV-1 infection is not associated with CTLA-4 polymorphisms in either HT or controls. HTLV-1 infection is not regulated by genetic factor such as CTLA-4, and may affect occurrence of HT as an independent purely environmental factor. | lld:pubmed |
| pubmed-article:12225635 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12225635 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12225635 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12225635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12225635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12225635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12225635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12225635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12225635 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12225635 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12225635 | pubmed:issn | 1050-7256 | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:TakasuNobuyuk... | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:MasudaMasatoM | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:KomiyaIchiroI | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:KinjoYoshinoY | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:TomoyoseTakea... | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:TakaraMasakiM | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:KoukiTsuyoshi... | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:ShimajiriYosh... | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:YabikuKouichi... | lld:pubmed |
| pubmed-article:12225635 | pubmed:author | pubmed-author:YogiHiroyukiH | lld:pubmed |
| pubmed-article:12225635 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12225635 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12225635 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12225635 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12225635 | pubmed:pagination | 673-7 | lld:pubmed |
| pubmed-article:12225635 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:12225635 | pubmed:meshHeading | pubmed-meshheading:12225635... | lld:pubmed |
| pubmed-article:12225635 | pubmed:meshHeading | pubmed-meshheading:12225635... | lld:pubmed |
| pubmed-article:12225635 | pubmed:meshHeading | pubmed-meshheading:12225635... | lld:pubmed |
| pubmed-article:12225635 | pubmed:meshHeading | pubmed-meshheading:12225635... | lld:pubmed |
| pubmed-article:12225635 | pubmed:meshHeading | pubmed-meshheading:12225635... | lld:pubmed |
| pubmed-article:12225635 | pubmed:meshHeading | pubmed-meshheading:12225635... | lld:pubmed |
| pubmed-article:12225635 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12225635 | pubmed:articleTitle | Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients. | lld:pubmed |
| pubmed-article:12225635 | pubmed:affiliation | Second Department of Internal Medicine, University of the Ryukyus School of Medicine, Nishihara, Okinawa, Japan. ttomoyos@estate.ocn.ne.jp | lld:pubmed |
| pubmed-article:12225635 | pubmed:publicationType | Journal Article | lld:pubmed |
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