| pubmed-article:12214664 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12214664 | lifeskim:mentions | umls-concept:C0032529 | lld:lifeskim |
| pubmed-article:12214664 | lifeskim:mentions | umls-concept:C0058253 | lld:lifeskim |
| pubmed-article:12214664 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12214664 | pubmed:dateCreated | 2002-9-6 | lld:pubmed |
| pubmed-article:12214664 | pubmed:abstractText | Mammalian flavin-containing monooxygenase (FMO) exists as six gene families and metabolizes a plethora of drugs and xenobiotics. The major FMO in adult human liver, FMO3, is responsible for trimethylamine (TMA) N-oxygenation. A number of FMO3 mutant alleles have been described and associated with a disease termed trimethylaminuria (TMAU). The TMAU patient excretes large amounts of TMA in urine and sweat. A more recent ethnically related polymorphism in expression of the major FMO in lung, FMO2, has been described. All Caucasians and Asians genotyped to date are homozygous for a CAG --> TAG amber mutation resulting in a premature stop codon and a nonfunctional protein truncated at AA 472 (wildtype FMO2 is 535 AA). This allele has been designated hFMO2*2A. Twenty-six percent of individuals of African descent and 5% of Hispanics genotyped to date carry at least one allele coding for full-length FMO2 (hFMO2*1 allele). Preliminary evidence indicates that FMO2.1 is very active toward the S-oxygenation of low MW thioureas, including the lung toxicant ethylene thiourea. Polymorphic expression of functional FMO2 in the individuals of African and Hispanic descent may markedly influence drug metabolism and/or xenobiotic toxicity in the lung. | lld:pubmed |
| pubmed-article:12214664 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12214664 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12214664 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12214664 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12214664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12214664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12214664 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12214664 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12214664 | pubmed:issn | 0360-2532 | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:KruegerSharon... | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:MartinSarah... | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:YuehMei-FeiMF | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:WilliamsDavid... | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:HinesRonald... | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:PhillipsIan... | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:DolphinColin... | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:RaucyJudy LJL | lld:pubmed |
| pubmed-article:12214664 | pubmed:author | pubmed-author:ShephardEliza... | lld:pubmed |
| pubmed-article:12214664 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12214664 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:12214664 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12214664 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12214664 | pubmed:pagination | 523-32 | lld:pubmed |
| pubmed-article:12214664 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12214664 | pubmed:meshHeading | pubmed-meshheading:12214664... | lld:pubmed |
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| pubmed-article:12214664 | pubmed:meshHeading | pubmed-meshheading:12214664... | lld:pubmed |
| pubmed-article:12214664 | pubmed:meshHeading | pubmed-meshheading:12214664... | lld:pubmed |
| pubmed-article:12214664 | pubmed:meshHeading | pubmed-meshheading:12214664... | lld:pubmed |
| pubmed-article:12214664 | pubmed:meshHeading | pubmed-meshheading:12214664... | lld:pubmed |
| pubmed-article:12214664 | pubmed:meshHeading | pubmed-meshheading:12214664... | lld:pubmed |
| pubmed-article:12214664 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12214664 | pubmed:articleTitle | Genetic polymorphisms of flavin-containing monooxygenase (FMO). | lld:pubmed |
| pubmed-article:12214664 | pubmed:affiliation | Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, USA. | lld:pubmed |
| pubmed-article:12214664 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12214664 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12214664 | pubmed:publicationType | Review | lld:pubmed |
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